Accès ouvert
2025
article
OpenAlex
Bhuvic Patel, Sangami Pugazenthi, Collin William English, Vijay Nitturi et autres
BACKGROUND: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown. …
us, ca
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
H. Josh Jang, Nakul M. Shah, Ju Heon Maeng, Yonghao Liang et autres
Abstract Epigenetic treatment has been studied as a means to augment anti-tumor immune cell activity by increasing the expression of antiviral response genes. Previous studies, including our own, have revealed an additional consequence of epigenetic treatment: reactivation of transposable elements (TEs). Normally, …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
H. Josh Jang, Nakul M. Shah, Ju Heon Maeng, Yonghao Liang et autres
us, gb
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Sangami Pugazenthi, Bhuvic Patel, Collin English, Tatenda Mahlokozera et autres
INTRODUCTION: Grade 2 meningiomas (G2Ms) are associated with an aggressive natural history characterized by recurrence and resistance to radiation therapy. Histopathological necrosis is associated with worse progression-free survival (PFS) following radiation therapy in G2Ms. We seek to understand the molecular pathophysiology of …
2024
article
OpenAlex
Bhuvic Patel, Thomas F. Barrett, Saad M. Khan, Riley Mullens et autres
Introduction: Sporadic vestibular schwannomas (VS) are benign tumors but can lead to significant neurologic and otologic morbidity. The treatment for growing or symptomatic VS consists of radiosurgery or open surgical resection, both of which are associated with morbidity. At present, the underlying …
us
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Accès ouvert
2024
article
OpenAlex
Thomas F. Barrett, Bhuvic Patel, Saad M. Khan, Riley Mullins et autres
Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to VS pathogenesis remains poorly understood. In this study, we perform scRNA-seq on 15 VS, with paired scATAC-seq (n …
us, gb
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Bhuvic Patel, Sangami Pugazenthi, Collin William English, Tatenda Mahlokozera et autres
ABSTRACT Background World Health Organization Grade 2 meningiomas (G2Ms) exhibit an aggressive natural history characterized by recurrence and therapy resistance. G2Ms with histopathological necrosis have been associated with worse local control (LC) following radiation therapy, but drivers and biomarkers of radiation resistance …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Thomas F. Barrett, Bhuvic Patel, Saad M. Khan, Aldrin Kay‐Yuen Yim et autres
ABSTRACT Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to the pathogenesis of these tumors remains poorly understood. We performed scRNA-seq on 15 VS samples, with paired …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Diane D. Mao, Ryan T. Cleary, Amit D. Gujar, Tatenda Mahlokozera et autres
Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 …
us
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2022
article
OpenAlex
Anja I. Srienc, Tatenda Mahlokozera, Michelle Connor, Peng Cheng Han et autres
BACKGROUND AND IMPORTANCE: Capillary hemangiomas are space-occupying lesions that rarely affect the central nervous system. When they present within the spinal canal, they can cause insidious symptoms and threaten neurological function. In this study, we present a case of an intradural extramedullary …
us
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Accès ouvert
2021
article
OpenAlex
Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick DeSouza et autres
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the …
us, gb
(code pays fourni par la source)
Accès ouvert
2021
conference-abstract
OpenAlex
Bhuvic Patel, Tatenda Mahlokozera, Hsiang‐Chih Lu, Alicia Yang et autres
Abstract World health organization grade 2 meningiomas (G2M) are associated with an aggressive natural history characterized by frequent recurrence, resistance to radiation therapy (RT), and poor survival. We and others have shown that intratumoral necrosis is an independent predictor of disease progression …
us, ca
(code pays fourni par la source)