Collin W. English

Characterizing symptom presentation in Chiari malformation type-1 in two subpopulations of pediatric patients who underwent decompression

Huy Dang, Collin W. English, Prazwal Athukuri, Alex Flores et autres

Background: Chiari malformation type-1 (CM1), or displacement of the cerebellar tonsils below the foramen magnum, causes symptoms through brainstem compression or obstruction of the flow of cerebrospinal fluid. Presenting symptoms have been shown to differ in children and adults. Pediatric patients at …

us (code pays fourni par la source)

NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas

Bhuvic Patel, Sangami Pugazenthi, Collin W. English, Vijay Nitturi et autres

BACKGROUND: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown. …

us, ca (code pays fourni par la source)

Role of NF2 Mutation in the Development of Eleven Different Cancers

Shervin Hosseingholi Nouri, Vijay Nitturi, Elizabeth Ledbetter, Collin W. English et autres

Background/Objectives: With the rise in prevalence of diagnostic genetic techniques like RNA sequencing and whole exome sequencing (WES), as well as biological treatment regiments for cancer therapy, several genes have been implicated in carcinogenesis. This review aims to update our understanding of …

us (code pays fourni par la source)

Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution

Sangami Pugazenthi, Bhuvic Patel, Collin W. English, William A. Leidig et autres

An important subset of meningiomas behaves aggressively and is characterized by multiple recurrences. We identify clinical, genetic, and epigenetic predictors of multiply recurrent meningiomas (MRMs) and evaluate the evolution of these meningiomas in patient-matched samples. On multivariable binomial logistic regression, MRMs were …

us (code pays fourni par la source)

Subpial resection of epileptogenic tubers: operative nuances and lessons learned

Nisha Giridharan, Collin W. English, Marcus Wong, Howard L. Weiner

Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder. Tubers of the central nervous system are a hallmark of the disorder and often cause epilepsy. Many TSC patients fail to achieve seizure control with medication alone. Several case series have demonstrated …

us (code pays fourni par la source)

Correction to: Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data

Arya Shetty, Su Wang, Abdul Wali Khan, Collin W. English et autres

us (code pays fourni par la source)

Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data

Arya Shetty, Su Wang, Abdul Wali Khan, Collin W. English et autres

us (code pays fourni par la source)

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome

H. Nayanga Thirimanne, Damian Almiron-Bonnin, Nicholas Nuechterlein, Sonali Arora et autres

Meningiomas, although mostly benign, can be recurrent and fatal. World Health Organization (WHO) grading of the tumor does not always identify high-risk meningioma, and better characterizations of their aggressive biology are needed. To approach this problem, we combined 13 bulk RNA sequencing …

us, Afrique du Sud, de, ca (code pays fourni par la source)

Leveraging Single-Cell Sequencing to Classify and Characterize Tumor Subgroups in Bulk RNA-Sequencing Data

Arya Shetty, Su Wang, Abdul Wali Khan, Collin W. English et autres

Abstract Accurate classification of cancer subgroups is essential for precision medicine, tailoring treatments to individual patients based on their cancer subtypes. In recent years, advances in high-throughput sequencing technologies have enabled the generation of large-scale transcriptomic data from cancer samples. These data …

us (code pays fourni par la source)

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome

H. Nayanga Thirimanne, Damian A. Almiron Bonnin, Nicholas Nuechterlein, Sonali Arora et autres

Summary Meningiomas, the most common intracranial tumor, though mostly benign can be recurrent and fatal. WHO grading does not always identify high risk meningioma and better characterizations of their aggressive biology is needed. To approach this problem, we combined 13 bulk RNA-Seq …

us, de, ca (code pays fourni par la source)

Case Report: Contralateral Progression of a Vestibular Schwannoma After Resection in a Patient with Neurofibromatosis Type 2

Ihika Rampalli, Collin W. English, Tyler Lazaro, Benjamin D. Lovin et autres

BACKGROUND AND IMPORTANCE: Bilateral vestibular schwannomas (VS) are a distinctive feature of neurofibromatosis type 2 (NF2) that result in a serious reduction in the quality of life for patients. The growth rates of these schwannomas are variable, and the early detection of …

us (code pays fourni par la source)

Meningioma Transcriptomic Landscape Demonstrates Novel Subtypes with Regional Associated Biology and Patient Outcome

H. Nayanga Thirimanne, Damian A. Almiron Bonnin, Nicholas Nuechterlein, Sonali Arora et autres

us, de, ca, my (code pays fourni par la source)