Minae Niwa

Reviewer #2 (Public review): Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers

Jose Francis-Oliveira, Rinako Tanaka, Matthew Shen, Emily Cruvinel et autres

Early-life adversity (ELA) can produce lasting alterations on brain and behavior, yet its effects on maternal caregiving and intergenerational social outcomes remain poorly understood. Using a mouse model of mild adolescent social isolation, we demonstrated that females exposed to isolation in late …

Reviewer #1 (Public review): Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers

Jose Francis-Oliveira, Rinako Tanaka, Matthew Shen, Emily Cruvinel et autres

Early-life adversity (ELA) can produce lasting alterations on brain and behavior, yet its effects on maternal caregiving and intergenerational social outcomes remain poorly understood. Using a mouse model of mild adolescent social isolation, we demonstrated that females exposed to isolation in late …

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FcγR- and CD9-dependent synapse-engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage in mice

Ken Matoba, Takahiro Kochi, Oluwaseun Fatoba, Md Sorwer Alam Parvez et autres

Abstract Chronic neuroinflammation gives rise to diverse microglial states across the brain, yet how region-specific microglial remodeling contributes to cognitive dysfunction remains unclear. Here we report that synapse-engulfing microglia in the thalamus drive cognitive impairment after cortical brain damage in mice, primarily …

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Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers

Jose Francis-Oliveira, Rinako Tanaka, Matthew Shen, Emily Cruvinel et autres

Abstract Early-life adversity (ELA) can produce lasting alterations on brain and behavior, yet its effects on maternal caregiving and intergenerational social outcomes remain poorly understood. Using a mouse model of mild adolescent social isolation, we demonstrated that females exposed to isolation in …

us, br (code pays fourni par la source)

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice

Ken Matoba, Eisuke Dohi, Phoebe A. Garcia, Jose Francis-Oliveira et autres

Abstract Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired …

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Estimation of α/β Ratio for Late Genitourinary Toxicity Following Salvage Radiotherapy for Biochemically Recurrent Prostate Cancer

Shingo Takano, Natsuo Tomita, Takehiro Takaoka, Minae Niwa et autres

FcγR- and CD9-dependent synapse engulfing microglia in the thalamus drives cognitive impairment following cortical brain injury

Ken Matoba, Takahiro Kochi, Yassin R Mreyoud, Jana H. Badrani et autres

Abstract Various states of microglia appear in neuroinflammation, but their impact on brain function and behavior is not fully understood. Here we report that synapse engulfing microglia in the thalamus are crucial for cognitive impairment after cortical brain injury. Region-specific manipulations of …

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Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in mice

Ken Matoba, Eisuke Dohi, Phoebe A. Garcia, José Fernando de Oliveira et autres

Abstract Extracellular vesicles (EVs) are cell-derived small membrane vesicles and circulate throughout the body, but the impact of circulating EVs on brain function and behavior remains elusive. Here, we report that wild-type (WT) mouse blood, particularly EVs, increases sociability in socially impaired …

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Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility

Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung et autres

The article Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility, written by Akira Sawa was originally published online on the publisher’s internet portal on 14.04.2024 with Open Access under a Creative Commons Attribution (CC BY) license 4.0.

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The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing.

Benjamin R. Fry, Victoria Fex, Akira Sawa, Minae Niwa et autres

A growing body of literature indicates that mediated learning techniques have specific utility for tapping into reality testing in animal models of neuropsychiatric illness. In particular, recent work has shown that animal models that recapitulate various endophenotypes of schizophrenia are particularly vulnerable …

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Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice

Owen Leitzel, José Fernando de Oliveira, Shaimaa M. Khedr, Lila Ariste et autres

Pregnancy and the postpartum period induce physiological changes that can influence women’s cognitive functions. Alzheimer’s disease (AD) has a higher prevalence in women and is exacerbated by early life stress. In the present study, we found that late adolescent social isolation combined …

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Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility

Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung et autres

We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks were elicited, the nuclear glyceraldehyde dehydrogenase (N-GAPDH) cascade was activated specifically in microglia in …

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