Sj Shen

Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome

Li Pan, Li Xie, Huimin Zheng, Yinglin Feng et autres

Abstract Polycystic ovary syndrome (PCOS) is a prevalent endocrine and reproductive disorder affecting women of reproductive age. While the gut microbiota has been implicated in PCOS pathophysiology, the role of microbial‐derived metabolites as mediators of host–microbe interactions remains poorly defined. Here, we …

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Study on flexural behavior of CO2 cured recycled coarse aggregate concrete steel bar trusses composite slab

Yueqing Gao, Sj Shen, Zeshen Li, Wei Wang et autres

The effects of aggregate carbonation, overall specimen carbonation, and the combined method of aggregate carbonation and overall specimen carbonation on the mechanical properties of recycled coarse aggregate concrete (RAC) were investigated. Furthermore, the flexural behaviors of steel bar trusses composite slab (SBTCS) …

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934: IMPACT OF THE GUT MICROBIOTA ON IMMUNE MODULATION AND RESPONSE TO IMMUNE CHECKPOINT INHIBITORS IN HEPATOCELLULAR CARCINOMA: INSIGHTS FROM HUMAN AND PRECLINICAL MODELS

Jayashi Rajapakse, Saroj Khatiwada, Sj Shen, Kin Lam Yu et autres

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease

Gang Liu, Alan Hsu, Silke Geirnaert, Christine Cong et autres

Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in chronic obstructive pulmonary disease (COPD) is unknown. We show that VTN regulates tissue remodeling through urokinase plasminogen activator (uPA) signaling pathway in COPD. In human COPD airways …

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Could intratumoural microbiota be key to unlocking treatment responses in hepatocellular carcinoma?

Kin Lam Yu, Sj Shen

Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide. Current treatments include surgery and immunotherapy with variable response. Despite aggressive treatment, disease progression remains the biggest contributor to mortality. Thus, there is an urgent unmet need to improve current treatments …

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Dietary patterns and cardiovascular diseases among Chinese high-risk population aged 35 years and older: A 6-year cohort study

Shanshan Chen, Shiyun Hu, Sj Shen, Jialin Zhang et autres

This study aims to investigate the dietary patterns of Chinese individuals aged 35 years and older who are at high risk of cardiovascular disease (CVD) and to explore the correlation between these dietary patterns and the risk of CVD. A total of …

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Associations between Multiple Food Consumption Frequencies and the Incidence of Cardiovascular Disease in High Cardiac Risk Subjects

Xiaohui Xu, Shiyun Hu, Sj Shen, Fang Ding et autres

Background: Dietary choices are inextricably linked to the incidence of cardiovascular disease (CVD), whereas an optimal dietary pattern to minimize CVD morbidity in high-risk subjects remains challenging. Methods: We comprehensively assessed the relationship between food consumption frequencies and CVD in 28,979 high-risk …

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Improvement of the spatial resolution of the spatial mapping of metallic coatings by using picosecond LIBS

Zhenzhen Wang, Sj Shen, Yuta Arima, Chi Li et autres

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β-resorcylic acid released by Limosilactobacillus reuteri protects against cisplatin-induced ovarian toxicity and infertility

Yinglin Feng, Huimin Zheng, Chunhua Yin, Dong Liang et autres

Chemotherapy-induced premature ovarian insufficiency (CIPOI) triggers gonadotoxicity in women undergoing cancer treatment, leading to loss of ovarian reserves and subfertility, with no effective therapies available. In our study, fecal microbiota transplantation in a cisplatin-induced POI mouse model reveals that a dysbiotic gut …

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Faecal microbial transfer and complex carbohydrates mediate protection against COPD

Kurtis F. Budden, Shakti Dhar Shukla, Kate L Bowerman, Annalicia Vaughan et autres

Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic …

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Fecal microbial transfer and complex carbohydrates mediate protection against COPD

Kurtis F. Budden, Shakti Dhar Shukla, Kate L Bowerman, Shaan L. Gellatly et autres

ABSTRACT Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in …

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Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions

Jayashi Rajapakse, Saroj Khatiwada, Anna Camille Akon, Kin Lam Yu et autres

Hepatocellular carcinoma (HCC) has been linked to the gut microbiota, with recent studies revealing the potential of gut-generated responses to influence several arms of the immune responses relevant to HCC formation. The pro- or anti-tumor effects of specific bacterial strains or gut …

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