Zhanyong Wei

Porcine deltacoronavirus nucleocapsid protein inhibits RIG-I signaling pathway by suppressing G3BP1-mediated stress granules formation

Meng Guo, Yating Hu, Donghan Wang, Yuxin Tang et autres

Porcine deltacoronavirus (PDCoV) is an emerging zoonotic pathogen causing severe diarrhea in suckling piglets. Stress granules (SGs), stress-induced cytoplasmic condensates, are pivotal to the antiviral innate immune response. However, the interaction between PDCoV and SGs remains unclear. Here, we found that PDCoV …

cn (code pays fourni par la source)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Jinhui Hou, Fangfang Han, Anqi Liu, Yi Yang et autres

Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, resulting substantial economic losses. The NLR family pyrin domain containing 3 (NLRP3) inflammasome, a key component of the innate immune system, drives interleukin (IL)-1β maturation, and its excessive activation …

cn (code pays fourni par la source)

Transcriptomic analysis reveals the host factor VCAM-1 affecting porcine delta coronavirus infection

Jiale Wei, Shiwen Li, Yi Xing, Feifei Wang et autres

cn (code pays fourni par la source)

Diagnostic Methods for Bovine Coronavirus: A Review of Recent Advancements and Challenges

Jie Dong, Xiaoxiao He, Shijun Bao, Zhanyong Wei

Bovine coronavirus(BCoV) is a significant pathogen causing substantial economic losses in the cattle industry through increased calf mortality, reduced growth performance, and decreased milk yield. Rapid and accurate diagnostic methods are therefore essential for controlling BCoV transmission. Current diagnostic methods comprise two …

cn (code pays fourni par la source)

Corrigendum to “Identification and characterization of linear B cell epitopes of monoclonal antibodies against the S2 subunit of porcine deltacoronavirus” [Int. J. Biol. Macromol. 323 (Part 1) (September 2025) 147116]

Runze Song, Xiao Ma, Junyao Yang, Huanhuan Liu et autres

cn (code pays fourni par la source)

Establishment and application of a dual chip digital PCR assay for detection of PDCoV and PEDV

Yue Zhang, Fangting Dong, Yuhang Zhang, Yutong Feng et autres

Introduction: Coinfection with porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) is a major cause of acute diarrhea in piglets, which poses a significant challenge to the swine industry. The early detection and control of these two viruses require highly sensitive …

cn (code pays fourni par la source)

Identification and characterization of linear B cell epitopes of monoclonal antibodies against the S2 subunit of porcine deltacoronavirus

Runze Song, Xiao Ma, Junyao Yang, Huanhuan Liu et autres

cn (code pays fourni par la source)

Outer membrane vesicles of Glaesserlla parasuis activate the endosomal cGAS–STING–IRF3 pathway through nucleic acid payload delivery: a biological perspective on host defense protocol optimization

Kunli Zhang, Zeyi Sun, Xintong Kang, Keda Shi et autres

Glaesserlla parasuis (G. parasuis), a Gram-negative pathogen responsible for Glässer's disease, employs outer membrane vesicles (OMVs) as sophisticated nanoscale effectors to modulate host‒pathogen interplay. While bacterial OMVs are recognized as critical mediators of virulence dissemination, their functional orchestration in G. parasuis immunopathogenesis …

cn (code pays fourni par la source)

Development of the coronavirus reverse genetic system: Core technology for pathogenesis mechanisms research and vaccine/drug development

Yue Zhang, Ruifeng Hou, Zhanyong Wei, Jin Yuan et autres

Coronaviruses (CoVs) are enveloped, single-stranded, positive-sense RNA viruses that cause respiratory, gastrointestinal, hepatic, and neurological diseases in humans and other animals. In recent years, frequent outbreaks of emerging and re-emerging CoVs have threatened animal and human health. However, an insufficient understanding of …

cn (code pays fourni par la source)

MHC-I pathway disruption by viruses: insights into immune evasion and vaccine design for animals

Yanan Wu, Zhuoya Sun, Lu Xia, Panpan Tian et autres

Among various pathogens, viruses pose significant threats to the livestock and poultry industry, resulting in substantial annual costs due to production losses and vaccination. The MHC-I presentation pathway is a crucial surveillance mechanism for preventing viral infections. Consequently, many viruses have evolved …

cn (code pays fourni par la source)

Yeast-Derived Manganese and Zinc Metal–Organic Framework Composite as a Vaccine Adjuvant for Enhanced Humoral and Cellular Immune Responses

Lan‐Lan Zheng, Zi Wang, Hang Liu, Nianxiang Wang et autres

To control pandemics, a universal adjuvant platform that can deliver antigens and stimulate the immune system that rapidly elicits humoral and cellular immune responses is needed, especially one that can stimulate the body's immune system to produce protective immunological memory. However, the …

cn (code pays fourni par la source)

Gut microbiota contributes to protection against porcine deltacoronavirus infection in piglets by modulating intestinal barrier and microbiome

Yunfei Zhang, Lulu Si, Xiangli Shu, Xianhua Wan et autres

BACKGROUND: Gut microbiota plays a critical role in counteracting enteric viral infection. Our previous study demonstrated that infection of porcine deltacoronavirus (PDCoV) disturbs gut microbiota and causes intestinal damage and inflammation in piglets. However, the influence of gut microbiota on PDCoV infection …

cn, th (code pays fourni par la source)