Xiangli Shu

Gut microbiota contributes to protection against porcine deltacoronavirus infection in piglets by modulating intestinal barrier and microbiome

Yunfei Zhang, Lulu Si, Xiangli Shu, Xianhua Wan et autres

BACKGROUND: Gut microbiota plays a critical role in counteracting enteric viral infection. Our previous study demonstrated that infection of porcine deltacoronavirus (PDCoV) disturbs gut microbiota and causes intestinal damage and inflammation in piglets. However, the influence of gut microbiota on PDCoV infection …

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Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets

Yunfei Zhang, Lulu Si, Junlong Gao, Xiangli Shu et autres

ABSTRACT Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that mainly causes diarrhea in suckling piglets, and also has the potential for cross-species transmission. However, there are still no commercial vaccines available to prevent and control PDCoV infection. In this study, PDCoV strain …

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Preparation of monoclonal antibody and identification of two novel B cell epitopes to VP1 protein of porcine sapelovirus

Chenlin Hao, Haojie Ren, Xingyi Wu, Xiangli Shu et autres

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Co-infection of porcine deltacoronavirus and porcine epidemic diarrhoea virus alters gut microbiota diversity and composition in the colon of piglets

Xiangli Shu, Fangfang Han, Yating Hu, Chenlin Hao et autres

Porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhoea virus (PEDV) are the main porcine enteric coronaviruses that cause severe diarrhoea in piglets, posing huge threat to the swine industry. Our previous study verified that the co-infection of PDCoV and PEDV is common in …

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Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic Cells

Lan‐Lan Zheng, Fujie Zhao, Jiaxi Ru, Lintao Liu et autres

A transmissible gastroenteritis virus (TGEV) is a porcine enteropathogenic coronavirus, causing acute swine enteric disease especially in suckling piglets. Mesoporous silica nanoparticles (MSNs) are safe vaccine adjuvant, which could enhance immune responses. Our previous research confirmed that nano silicon had immune-enhancing effects …

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Co‐infection of porcine epidemic diarrhoea virus and porcine deltacoronavirus enhances the disease severity in piglets

Honglei Zhang, Fangfang Han, Xiangli Shu, Qianqian Li et autres

Porcine epidemic diarrhoea virus (PEDV) and porcine deltacoronavirus (PDCoV) are the main enteric coronaviruses that cause acute diarrhoea and dehydration in pigs. The co-infection of PDCoV and PEDV is common in natural swine infections, but the clinical outcomes of the interaction between …

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Prevalence and phylogenetic analysis of spike gene of porcine epidemic diarrhea virus in Henan province, China in 2015–2019

Honglei Zhang, Fangfang Han, Xiaoguang Yan, Lintao Liu et autres

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Assessments of different inactivating reagents in formulating transmissible gastroenteritis virus vaccine

Fujie Zhao, Lintao Liu, Menglong Xu, Xiangli Shu et autres

Abstract Background Transmissible gastroenteritis virus (TGEV) causes enteric infection in piglets, characterized by vomiting, severe diarrhea and dehydration, and the mortality in suckling piglets is often high up to 100%. Vaccination is an effective measure to control the disease caused by TGEV. …

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Assessments of different inactivating reagents in formulating transmissible gastroenteritis virus vaccine

Fujie Zhao, Lintao Liu, Menglong Xu, Xiangli Shu et autres

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Assessments of immune response to vaccines of transmissible gastroenteritis virus inactivated by different agents

Fujie Zhao, Liu LinTao, Menglong Xu, Xiangli Shu et autres

Abstract Background: Transmissible gastroenteritis virus (TGEV) could cause swine enteric infection, which is characterized by vomiting, severe diarrhea and dehydration, and the mortality in suckling piglets is often high up to 100%. Vaccination is an effective measure to control the disease caused …

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Preliminary studies on the hosts range of wheat rosette disease caused by northern cereal mosaic virus.

S. Zhang, Xiangli Shu, Changliang Fu, Zhaoguang Li et autres