Zhitong Zhou

SGLT2 inhibitor ameliorates hypertension by regulating the CYP4A/20-HETE pathway in the kidney

Zhitong Zhou, Weijian Hang, Rui Zhao, Jiangang Jiang et autres

Sodium-glucose transport protein 2 inhibitors (SGLT2i), initially developed as antidiabetic agents and now established as foundational therapies for heart failure, have also shown antihypertensive effects in clinical trials involving patients with diabetes and heart failure. However, the underlying mechanisms remain incompletely understood. …

pl, cn (code pays fourni par la source)

Robust Quantum Cutting via Halide-Bearing Ligand Passivation and Gradient Halide Reconstruction for Ultrabroadband Ultraviolet-to-Near-Infrared Photodetection and Imaging

Yutao Yang, Fengqian Chen, Xiachu Xiao, Yi-Xiang Wang et autres

Soft-lattice nanocrystal photon management hinges on controlling relaxation branching, diverting excitations from interfacial losses into radiative pathways. CsPbCl3:Yb3+ quantum cutting benchmarks this, but is still constrained by surface trapping, suboptimal Yb-pair branching energetics, and limited thermal/environmental stability. Here we implement a (2-bromoethyl)trimethylammonium …

us, cn, gb (code pays fourni par la source)

Novel inflammatory biomarkers enhance prediction of sepsis-associated acute kidney injury: a machine learning approach

Yu Zhang, Xiaotong Han, Siyu Lu, Yuteng Zeng et autres

Background: Sepsis-associated acute kidney injury (S-AKI) is a common complication of sepsis, and early identification can improve patient prognosis. This study incorporated novel inflammatory markers as features to construct a model and employed 6 machine learning methods to predict the occurrence of …

cn (code pays fourni par la source)

Folic acid mitigation of alcohol-induced sarcopenia via gut-muscle axis modulation

Nan Zhang, Jing Shi, Huaqi Zhang, Zhitong Zhou et autres

cn (code pays fourni par la source)

Dual enhancement of mycoprotein nutrition and sustainability via CRISPR-mediated metabolic engineering of Fusarium venenatum

Xiaohui Wu, Mengru Wang, Shijun Luo, Zhitong Zhou et autres

cn, nl (code pays fourni par la source)

A Shared Adenocarcinoma Transcriptomic Program Enables Prediction of Therapeutics Applicable Across Tissues

Zhitong Zhou, Christopher B. Lietz

Abstract Background Adenocarcinomas are malignancies arising from glandular epithelial cells or secretory tissue, and account for most cancer-related mortalities worldwide, despite advances in treatment. New treatments are often developed in the context of the organ from which the tumor originates. However, there …

us (code pays fourni par la source)

Enhanced mycoprotein extraction via cell wall disruption: A promising alternative protein with preferable digestibility and lubrication over soy protein

Zhitong Zhou, Yingying Jin, Xiaohui Wu, Yu‐Kang Tu et autres

cn (code pays fourni par la source)

Ru-Co single-atom alloy catalysts for efficient amination of alcohols: A synergistic effect

Zhitong Zhou, Weixiang Guan, Xiaoli Pan, Shengxin Zhang et autres

cn (code pays fourni par la source)

Research on the spinning forming process of 30CrMnSiA/304 bimetallic composite tube

Yaming Guo, Zheng Yuan, Tao Huang, Hengqiu Xu et autres

Abstract In order to improve the forming quality, finite element analysis was carried out on the stress-strain, shear bonding strength, wall thickness, and residual contact stress of 30CrMnSiA/304 bimetallic composite tube. The results show that the force of the base pipe is …

cn (code pays fourni par la source)

Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway

Yuan Wang, Wentao Liu, Chen Liu, Zhitong Zhou et autres

We demonstrated for the first time that asprosin (ASP) has protective effects against diabetic cardiomyopathy. We found that ASP could stimulate the AMPK/mTOR/ULK1 pathway to reduce the level of autophagy and apoptosis of cardiomyocytes, thereby maintaining the normal physiological function of the …

cn (code pays fourni par la source)

Predicting Short-Term Risk of Cardiovascular Events in the Elderly Population: A Retrospective Study in Shanghai, China

Wenqing Zhu, Shuoyuan Tan, Zhitong Zhou, Miaomiao Zhao et autres

Introduction: Cardiovascular diseases (CVD) represents a leading cause of morbidity and mortality worldwide, including China. Accurate prediction of CVD risk and implementation of preventive measures are critical. This study aimed to develop a short-term risk prediction model for CVD events among individuals …

cn (code pays fourni par la source)

Synthesis of Pyrazines from Biomass-Derived Vicinal Diols Using Ammonia over Heterogeneous Pt/CeO2/Al2O3 Catalysts

Zhitong Zhou, Weixiang Guan, Xiaoli Pan, Aiqin Wang et autres

One-pot amination coupling of vicinal diols toward the synthesis of pyrazines provides an efficient and economically viable route to access N-heterocycles from biomass, yet the current methodology relies on a fragile homogeneous catalyst system, which limits the sustainability of the chemistry. In …

cn (code pays fourni par la source)