Accès ouvert
2025
preprint
OpenAlex
Zhitong Zhou, Christopher B. Lietz
Abstract Background Adenocarcinomas are malignancies arising from glandular epithelial cells or secretory tissue, and account for most cancer-related mortalities worldwide, despite advances in treatment. New treatments are often developed in the context of the organ from which the tumor originates. However, there …
us
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Accès ouvert
2024
article
OpenAlex
Sarah Trimpin, Frank S. Yenchick, Chuping Lee, Khoa Hoang et autres
This Perspective covers discovery and mechanistic aspects as well as initial applications of novel ionization processes for use in mass spectrometry that guided us in a series of subsequent discoveries, instrument developments, and commercialization. Vacuum matrix-assisted ionization on an intermediate pressure matrix-assisted …
us, tw, de, ph
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Accès ouvert
2024
preprint
OpenAlex
Christopher B. Lietz, Erik T. Newman, Andrew D. Kelly, David Haosen Xiang et autres
ABSTRACT Osteosarcoma is a rare primary bone tumor for which no significant therapeutic advancement has been made since the late 1980s despite ongoing efforts. Overall, the five-year survival rate remains about 65%, and is much lower in patients with tumors unresponsive to …
us, ca
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Accès ouvert
2024
article
OpenAlex
Sarah Trimpin, Ellen D. Inutan, Vincent S. Pagnotti, Santosh Karki et autres
This paper covers direct sub-atmospheric pressure ionization mass spectrometry (MS). The discovery, applications, and mechanistic aspects of novel ionization processes for use in MS that are not based on the high-energy input from voltage, laser, and/or high temperature but on sublimation/evaporation within …
us, ph, tw
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Accès ouvert
2024
article
OpenAlex
Sonia Podvin, Jeffrey R. Jones, Austin Kang, Ryan Goodman et autres
Schizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with behavioral symptoms that include hallucinations, delusions, disorganized behavior, and cognitive impairment. Regulation of such behaviors requires utilization of neurotransmitters released to mediate cell-cell communication which are essential to brain functions …
us
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Accès ouvert
2023
article
OpenAlex
Christopher B. Lietz, Ekaterina G. Deyanova, Younhee Cho, Jon F. Cordia et autres
Despite tyrosine sulfation being a relatively common post-translational modification (PTM) on the secreted proteins of higher eukaryotic organisms, there have been surprisingly few reports of this modification occurring in recombinant monoclonal antibodies (mAbs) expressed by mammalian cell lines and even less information …
de, us
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Accès ouvert
2022
article
OpenAlex
Christopher B. Lietz, Erik T. Newman, Andrew D. Kelly, David Haosen Xiang et autres
Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA methylation patterns have been shown to provide clinically useful prognostic information and define molecular disease subtypes with different response to therapy and long-term outcome. Osteosarcoma is an aggressive malignancy …
us, ca
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Accès ouvert
2021
article
OpenAlex
Michael C. Yoon, Angelo Solania, Zhenze Jiang, Mitchell P. Christy et autres
Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B translocates to the cytosol having neutral pH where the enzyme activates inflammation and cell death. Cathepsin B is active at …
us
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Accès ouvert
2021
article
OpenAlex
Zhenze Jiang, Christopher B. Lietz, Sonia Podvin, Michael C. Yoon et autres
Neuropeptides mediate cell-cell signaling in the nervous and endocrine systems. The neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within dense core secretory vesicles (DCSV). DCSV neuropeptides and contents are released to the extracellular environment where further processing for …
us
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Accès ouvert
2021
article
OpenAlex
Sonia Podvin, Alexander Curtis Jones, Qing Huo Liu, Brent D. Aulston et autres
injection. To gain insights into the exosome proteome cargo that participates in propagating tau pathology, this study conducted proteomic analysis of exosomes produced by human iPSC neurons expressing A246E mPS1. Significantly, mPS1 altered the profile of exosome cargo proteins to result in …
us
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Accès ouvert
2020
preprint
OpenAlex
Christopher B. Lietz, Erik T. Newman, Andrew D. Kelly, Santiago A. Lozano‐Calderón et autres
ABSTRACT Background Osteosarcoma (OSA) is an aggressive malignancy predominantly affecting children and young-adults. Genetic analysis has characterized very few recurrent mutations in OSA, and an improved understanding of interpatient tumor heterogeneity is needed for clinical management. Methods We analyzed genome-wide DNA methylation …
us, ca
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Accès ouvert
2020
article
OpenAlex
Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Luis Negri et autres
Proteomic technologies have identified 234 peptidases in plasma but little quantitative information about the proteolytic activity has been uncovered. In this study, the substrate profile of plasma proteases was evaluated using two nano-LC-ESI-MS/MS methods. Multiplex substrate profiling by mass spectrometry (MSP-MS) quantifies …
it, us
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