P. Böhm

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger et autres

Peloruside A, a polyketide macrolide identified in the marine sponge Mycale hentscheli, is a promising anticancer drug candidate due to its ability to stabilize tubulin at a nontaxoid binding site. Substantial efforts were made to improve the supply of this scarce substance …

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Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger et autres

ABSTRACT Peloruside A, a polyketide macrolide identified in the marine sponge Mycale hentscheli , is a promising anticancer drug candidate due to its ability to stabilize tubulin at a nontaxoid binding site. Substantial efforts were made to improve the supply of this …

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Hijacking a bacterial ABC transporter for genetic code expansion

Tarun Iype, Maximilian Fottner, P. Böhm, Carlos Piedrafita et autres

Abstract The site-specific encoding of non-canonical amino acids (ncAAs) provides a powerful tool for expanding the functional repertoire of proteins 1–4 . Its widespread use for basic research and biotechnological applications is, however, hampered by the low efficiencies of current ncAA incorporation …

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Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases

Rosalie Lipsh‐Sokolik, P. Böhm, Clara Chepkirui, Jörn Piel

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KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally

Jakob M. Silberberg, Sophie Ketter, P. Böhm, Kristin Jordan et autres

Two-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli. Here, we identify a tandem serine histidine kinase function for KdpD, previously described as a histidine kinase of …

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Sensory kinase KdpD is a tandem serine histidine kinase controlling K + pump KdpFABC on the translational and post-transcriptional level

Jakob M. Silberberg, Sophie Ketter, P. Böhm, Kristin Jordan et autres

Abstract Two-component systems (TCSs), consisting of a histidine kinase (HK) and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli. Here, we identify a tandem serine histidine kinase function for KdpD, previously described as a …

de (code pays fourni par la source)

Adenoviruses : models and vectors in virus host interactions : immune system, oncogenesis, gene therapy

Walter Doerfler, P. Böhm

Adenoviruses : models and vectors in virus-host interactions : virion-structure, viral replication and host-cell interactions

Walter Dörfler, P. Böhm

Biology and pathogenesis

Walter Doerfler, P. Böhm

Molecular biology of virus-cell interactions

Walter Doerfler, P. Böhm

Virion structure and infection

Walter Doerfler, P. Böhm

Malignant transformation by DNA viruses. Molecular mechanisms.

Walter Doerfler, P. Böhm