Sonja Charlotte Schriever

Central Thyroid Hormone Deprivation Disrupts Cortical Cilia and Oligodendrocyte Lineage in an Allan–Herndon–Dudley Syndrome Mouse Model

Anna Molenaar, Ekta Pathak, Miriam Bernecker, Noémi Mallet et autres

BACKGROUND: Allan-Herndon-Dudley syndrome (AHDS) is an X-linked neurodevelopmental disorder caused by loss of the thyroid hormone (TH) transporter MCT8, resulting in central TH deprivation and disrupted cortical maturation, cognition, and motor control. MCT8/OATP1C1 double-knockout (dKO) mice faithfully model the human disease, recapitulating …

de, mx (code pays fourni par la source)

Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance

Claudia Kiermayer, Rebecca Erdelen, Sonja Charlotte Schriever, Ramona Böhm et autres

The mitochondrial selenoenzyme thioredoxin reductase 2 (TXNRD2) plays a critical role in redox homeostasis and reactive oxygen species ( ROS) scavenging. While heart-specific deletion of Txnrd2 in mice resulted in cardiac dysfunction, TXNRD2 function in skeletal muscle, the major component of lean …

de (code pays fourni par la source)

A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss

Natalie Taege, Jan H. Britsemmer, Andreas Israel, Christin Krause et autres

expression differences in a state of obesity.

de (code pays fourni par la source)

Central T3 deprivation disturbs cortical cilia formation, oligodendrocyte lineage and neuronal cell-cell-communication in a MCT8/OATP1C1 deficient Allan-Herndon-Dudley Syndrome mouse model

Anna Molenaar, Ekta Pathak, Miriam Bernecker, Noémi Mallet et autres

Abstract Background The Allan-Herndon-Dudley syndrome (AHDS) is a rare, X-linked human genetic disorder caused by mutations in the monocarboxylate transporter 8 (MCT8), essential for thyroid hormone (TH) transport across the blood-brain-barrier. The resulting central TH deprivation disrupts brain maturation and function, leading …

de (code pays fourni par la source)

A novel tamoxifen-inducible Mct8-CreERT2 mouse model for targeted studies of Mct8-expressing cells and thyroid hormone transport and function

Anna Molenaar, Noémi Mallet, Marin Bralo, Luciano Hoeher et autres

Deficiency of the Monocarboxylate Transporter 8 (MCT8) severely impairs thyroid hormone (TH) transport into the brain, disrupting brain development as well as peripheral TH homeostasis. Studies assessing MCT8 expression patterns and tissue-specific pathologies induced by local TH-deficiency are often inconclusive due to …

de, tr (code pays fourni par la source)

Low-to-Moderate Dosed Cranial Irradiation in Young Mice Induces Sex-Specific Metabolic Disturbances Later in Life

Luke P. Harrison, Sonja Charlotte Schriever, Miriam Bernecker, Noémi Mallet et autres

Survivors of childhood cancers who received high doses (40-60 Gy) of cranial irradiation (CI) have increased risks of developing obesity, type 2 diabetes, and metabolic syndrome (MetS). Here, we subjected mice to CI of 0, 0.5, or 2 Gy directed to the …

de (code pays fourni par la source)

Low-moderate dosed cranial irradiation in young mice induces sex specific metabolic disturbances later in life

Luke P. Harrison, Sonja Charlotte Schriever, Miriam Bernecker, Noémi Mallet et autres

Survivors of childhood cancers who received high doses (40-60 Gy) of cranial irradiation (CI) have increased risks of developing obesity, type 2 diabetes, and metabolic syndrome (MetS). Here, we subjected mice to CI of 0, 0.5, or 2 Gy directed to the …

Low-moderate dosed cranial irradiation in young mice induces sex specific metabolic disturbances later in life

Luke P. Harrison, Sonja Charlotte Schriever, Miriam Bernecker, Noémi Mallet et autres

Survivors of childhood cancers who received high doses (40-60 Gy) of cranial irradiation (CI) have increased risks of developing obesity, type 2 diabetes, and metabolic syndrome (MetS). Here, we subjected mice to CI of 0, 0.5, or 2 Gy directed to the …

NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo

Inderjeet Singh, Yasuhiro Onogi, Filipe Menezes, Dina Khasanova et autres

Adipose tissue is a central organiser of systemic lipid homeostasis and a pharmacological target in obesity, orchestrating cellular responses to environmental cues. Nutritionally regulated adipose and cardiac enriched protein (NRAC) is a small adipocyte-specific transmembrane protein with unknown function. Here, we show …

de, jp, ch (code pays fourni par la source)

A Novel Tamoxifen-Inducible Mct8-CreERT2 Mouse Model for Targeted Studies of Mct8-Expressing Cells and Thyroid Hormone Transport and Function

Anna Molenaar, Noémi Mallet, Marin Bralo, Luciano Hoeher et autres

de (code pays fourni par la source)

Weight cycling exacerbates glucose intolerance and hepatic triglyceride storage in mice with a history of chronic high fat diet exposure

Miriam Bernecker, Annette Feuchtinger, Anna Molenaar, Sonja Charlotte Schriever et autres

BACKGROUND: Obese subjects undergoing weight loss often fear the Yoyo dieting effect, which involves regaining or even surpassing their initial weight. To date, our understanding of such long-term obesity and weight cycling effects is still limited and often based on only short-term …

de (code pays fourni par la source)

EasyAb: A High-Throughput Workflow for Antibody-Based PTM Peptide Enrichment Method Coupled to Mass Spectrometry

Ashok Kumar Jayavelu, Jeffrey J. Liu, Sonja Charlotte Schriever, Paul Thomas Pfluger et autres

SUMMARY Reversible post-translational modification (PTMs) is a fundamental mechanism of cellular signal transduction. In vivo and ex vivo studies to profile PTMs have greatly advanced our understanding of the complexities of cellular signaling. However, apart from the most commonly studied PTMs, large-scale …

de, at (code pays fourni par la source)