Annette Feuchtinger

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

Manuel Gil‐Lozano, Estefanía Simoes, Moya Wu, Tobias Wiedemann et autres

Non-coding RNAs from the Dlk1-Dio3 locus are critical for the maturation of metabolic tissues in early stages of postnatal development; however, their role in the mature organs remains elusive. Herein, we show that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in …

de, ca, es, gb (code pays fourni par la source)

GLP-1RGIPRPPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

Daniela Liśkiewicz, Aaron Novikoff, Khalil A, Seun Akindehin et autres

Publisher Correction: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

Daniela Liśkiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin et autres

In the version of this article initially published, there were errors in the Fig. 4d colour key labels, where the label now reading “GLP-1-GIP–Lani” alongside the red filled circle originally indicated “GLP-1”, while the label now reading “GLP-1–Lani” alongside the white open …

de, us, fr, dk, se, cn, pl, es, nl, hu, sk (code pays fourni par la source)

GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

Daniela Liśkiewicz, Aaron Novikoff, Ahmed Khalil, Seun Akindehin et autres

Abstract There are increasing numbers of effective drugs to improve obesity-linked metabolic dysfunction; GLP-1R–GIPR co-agonism is effective in the management of obesity and type 2 diabetes 1,2 , and lanifibranor—a nuclear-acting small-molecule triple agonist of PPARα, PPARγ and PPARδ—is in clinical phase …

de, us, fr, dk, se, cn, pl, es, nl, hu, sk (code pays fourni par la source)

Spatial transcriptomics maps distinct signatures of human intermuscular adipose expansion in mice

Ekta Pathak, Robby Zachariah Tom, M. A. Kim, Stephan Sachs et autres

Intermuscular adipose tissue expansion is closely associated with cardiometabolic disease, yet its cellular organization and regulatory mechanisms remain poorly defined. Using bulk transcriptomics on human intermuscular adipose tissue, we identified a distinct gene signature and functional regulators including adipogenic transcription factor early …

de, us (code pays fourni par la source)

A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss

Natalie Taege, Jan H. Britsemmer, Andreas Israel, Christin Krause et autres

expression differences in a state of obesity.

de (code pays fourni par la source)

sNIR: A novel NIR dye for precision fluorescence-guided surgery

Oliver T. Bruns†, Merle M. Weitzenberg, Gina Fürtjes, Martin Ullrich et autres

de, se (code pays fourni par la source)

Neural CXCR4 contributes to neuroimmune modulation of atherosclerosis in a cardio-metabolic Ldlr⁻/⁻ mouse model

Yaqi Sun, Robby Zachariah Tom, Anna Goetz, Sebastian Cucuruz et autres

Abstract Background Atherosclerosis is a chronic inflammatory disease characterized by metabolic and immune dysregulation. Emerging evidence suggests that specific central nervous system (CNS) regions modulate its progression via neuroimmune cardiovascular interfaces (NICIs). While the C-X-C motif chemokine receptor 4 (CXCR4) is known …

de, nl, ch, sk (code pays fourni par la source)

Generating dermatopathology reports from gigapixel whole slide images with HistoGPT

Manuel Tran, Paul Schmidle, Ruifeng Guo, Sophia J. Wagner et autres

Histopathology is the reference standard for diagnosing the presence and nature of many diseases, including cancer. However, analyzing tissue samples under a microscope and summarizing the findings in a comprehensive pathology report is time-consuming, labor-intensive, and non-standardized. To address this problem, we …

de, us, nl (code pays fourni par la source)

Long-Acting Human PASylated Leptin Reaches the Murine Central Nervous System and Offers Potential for Optimized Replacement Therapy

Volker Morath, Stefanie F. Maurer, Annette Feuchtinger, Rebecca Walser et autres

High Resolution Image Download MS PowerPoint Slide Despite the multifaceted role of leptin for energy homeostasis and its broad therapeutic potential, the FDA/EMA-approved metreleptin constitutes the only leptin drug to date. To translate the promising results from previous studies on murine PASylated …

gb, de (code pays fourni par la source)

Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma

Qian Wang, Na Sun, Chaoyang Zhang, Thomas Kunzke et autres

Metabolic processes are crucial in immune regulation, yet the impact of metabolic heterogeneity on immunological functions remains unclear. Integrating metabolomics into immunology allows the exploration of the interactions of multilayered features in the biological system and the molecular regulatory mechanism of these …

us, de, ch (code pays fourni par la source)

Photoswitching protein-XTEN fusions as injectable optoacoustic probes

Mariia Stankevych, Vipul Gujrati, Uwe Klemm, Mohammed Arshad et autres

Optoacoustic imaging (OAI) is a unique in vivo imaging technique combining deep tissue penetration with high resolution and molecular sensitivity. OAI relying on strong intrinsic contrast, such as blood hemoglobin, already shows its value in medical diagnostics. However, OAI sensitivity to current …

de (code pays fourni par la source)