Lucile Grzesiak

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer

Eoghan J. Mulholland-Illingworth, Joshua W. Moore, Muyang Lin, Raheleh Amirkhah et autres

, reconfiguring local immune neighborhoods and indirectly altering epithelial stem cell states. Finally, we demonstrate that multiscale spatial analysis provides a quantitative readout of stromal-immune-epithelial remodeling following therapy. These findings establish a simplified, translationally relevant CAF framework and highlight spatially resolved stromal …

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MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

Mark White, Megan L. Mills, Laura M. Millett, Kathryn Gilroy et autres

Abstract The colorectal epithelium is rapidly renewing, with remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted to drive epithelial plasticity. Although oncogenic MAPK signalling in CRC is common, with frequent mutations of both KRAS …

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Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification

Lucile Grzesiak, Ana Amaya-Garrido, Guylène Feuillet, Nicole Malet et autres

Atherosclerosis is the primary cause of cardiovascular disease. The development of plaque complications, such as calcification and neo-angiogenesis, strongly impacts plaque stability and is a good predictor of mortality in patients with atherosclerosis. Despite well-known risk factors of plaque complications, such as …

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Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease

Ana Amaya-Garrido, Manon Brunet, Bénédicte Buffin‐Meyer, Alexis Piedrafita et autres

Vascular calcification is an important risk factor for cardiovascular (CV) mortality in patients with chronic kidney disease (CKD). It is also a complex process involving osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) and abnormal deposition of minerals in the vascular wall. …

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Role of leucine-rich alpha-2 glycoprotein 1 (LRG1) in the development of plaque complications

Lucile Grzesiak

L’athérosclérose est l’une des premières causes des maladies cardiovasculaires. Le développement de complications de plaque telles que la calcification et l’angiogénèse intra-plaque influence grandement la stabilité de la plaque et donc le pronostic vital du patient. Certains facteurs de risque sont connus …

Rôle de la leucine-rich alpha-2 glycoprotein 1 (LRG1) dans le développement de complications de plaque

Lucile Grzesiak

L’athérosclérose est l’une des premières causes des maladies cardiovasculaires. Le développement de complications de plaque telles que la calcification et l’angiogénèse intra-plaque influence grandement la stabilité de la plaque et donc le pronostic vital du patient. Certains facteurs de risque sont connus …

fr (code pays fourni par la source)

The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest

Ioanna Leontiou, Nitobe London, Karen May, Yingrui Ma et autres

The spindle checkpoint monitors kinetochore-microtubule interactions and generates a "wait anaphase" delay when any defects are apparent [1–3]. This provides time for cells to correct chromosome attachment errors and ensure high-fidelity chromosome segregation. Checkpoint signals are generated at unattached chromosomes during mitosis. …

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