Pedro Gonçalves

Acute peritonitis-induced adipose CD127+ ILC1s express PD-L1 and ameliorate inflammation in mice

Ritsu Nagata, Yuichi Akama, Pedro Gonçalves, Nicolas Serafini et autres

Peritonitis is an inflammation of the peritoneum primarily caused by gut perforation and consequent bacterial leakage, a known cause of sepsis. Although adipose tissue is recognized as an immunologically active organ, the involvement of adipose tissue innate lymphoid cells (ILC) in regulating …

jp, fr (code pays fourni par la source)

Wall Radiant Panels: Thermal Comfort Enhancement

P. Capela, Pedro Gonçalves, Ana Maria de Figueiredo Beltrão Corrêa de ARAÚJO, Pedro Lobarinhas et autres

Abstract Thermal comfort is essential for the quality of indoor environments, influencing the well-being of their occupants. The conventional air conditioning systems, based on convection, are facing challenges related to energy consumption, uneven temperature distribution and air movements and quality. In this …

pt, sk (code pays fourni par la source)

Adaptive immune responses to SARS-CoV-2 in DMARD-treated patients with chronic inflammatory rheumatisms

Maxime Beretta, Emmanuel Martin, O. Fogel, Clementina López‐Medina et autres

Background Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) are at an increased risk for infection related to the use of immunomodulatory therapies (ITs). The objective of this study is to assess the impact of ITs on the adaptive immune responses to …

fr, es (code pays fourni par la source)

Cycle assessment of a four-stroke spark-ignition ethanol fueled engine

Pedro Gonçalves, Pedro F.V. Carvalheira

A pathway that displaces current internal combustion engines (ICE) with more sustainable alternatives is required to achieve net zero emissions by 2050. A conceptual framework for an ICE was developed to understand this transition. The conceptual framework of this study was built …

pt (code pays fourni par la source)

2022 Edition of the Large Scale Exercise REPMUS: Field Report

João Costa, Paulo Sousa Dias, Ricardo Jorge Santos, Jorge Neiva et autres

This paper aims to share contributions and results of the REPMUS22 large-scale unmanned vehicle exercise to the marine robotics community, of which Underwater Systems and Technology Laboratory (LSTS) took part. Seven exercises were planned and we deployed a command, control, and communications …

pt (code pays fourni par la source)

Trained ILC3 responses promote intestinal defense

Nicolas Serafini, Angélique Jarade, Laura Surace, Pedro Gonçalves et autres

Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the impact of a time-restricted enterobacterial challenge to long-term ILC3 activation in mice. …

fr, us, gb (code pays fourni par la source)

Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency

Pedro Gonçalves, Jean‐Marc Doisne, Toshiki Eri, Bruno Charbit et autres

Both innate and adaptive lymphocytes have critical roles in mucosal defense that contain commensal microbial communities and protect against pathogen invasion. Here we characterize mucosal immunity in patients with severe combined immunodeficiency (SCID) receiving hematopoietic stem cell transplantation (HSCT) with or without …

fr (code pays fourni par la source)

Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study

Blandine Monel, Delphine Planas, Ludivine Grzelak, Nikaïa Smith et autres

BACKGROUND: The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised. METHODS: We measured infectious viral release, antibodies and cytokines in 426 PCR+ nasopharyngeal swabs from individuals harboring non-alpha or alpha variants. FINDINGS: infectious units. …

fr (code pays fourni par la source)

Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein

Marion Gransagne, Gabriel Aymé, Sébastien Brier, Gaëlle Chauveau-Le Friec et autres

The current COVID-19 pandemic illustrates the importance of obtaining reliable methods for the rapid detection of SARS-CoV-2. A highly specific and sensitive diagnostic test able to differentiate the SARS-CoV-2 virus from common human coronaviruses is therefore needed. Coronavirus nucleoprotein (N) localizes to …

fr (code pays fourni par la source)

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

Nikaïa Smith, Pedro Gonçalves, Bruno Charbit, Ludivine Grzelak et autres

Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against coronavirus disease 2019 (COVID-19) pathologies or fail, leading to severe clinical outcomes. To understand this process, we performed an integrated analysis of SARS-CoV-2 …

fr (code pays fourni par la source)

A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

Camille de Cevins, Marine Luka, Nikaïa Smith, Sonia Meynier et autres

fr, us (code pays fourni par la source)

Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-B.1.1.7 or B.1.1.7 SARS-CoV-2 variants

Blandine Monel, Delphine Planas, Ludivine Grzelak, Nikaïa Smith et autres

Abstract The mechanisms that allowed for the SARS-CoV-2 B.1.1.7 variant to rapidly outcompete pre-existing variants in many countries remain poorly characterized. Here, we analyzed viral release, anti-SARS-CoV-2 antibodies and cytokine production in a retrospective series of 427 RT–qPCR+ nasopharyngeal swabs collected in …

fr (code pays fourni par la source)