Alba Angelina

Innate immunity in allergic diseases: Novel concepts

Angel Maldonado, Alba Angelina, Natalia Cuervo, Sofía Sirvent et autres

Dysregulation of type 2 immunity, which normally protects the host against large parasites, toxins, and venoms, leads to aberrant inflammatory responses underlying several allergic diseases. Recent advances have highlighted the important role of innate immune responses in the initiation and persistence of …

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Type 2 Endotypes in Airway Diseases

Angel Maldonado, Malena del Campo-Grijalba, Alba Angelina, Oscar Palomares

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IgE, anti-IgE therapy, and regulatory T cells: new paradigms in allergic inflammation

C. Benito-Villalvilla, Alba Angelina, L. Martín-Cruz, Sofía Sirvent et autres

Allergic inflammation arises from a dysregulated immune response in which immunoglobulin E (IgE) plays a central pathogenic role. By binding to its high-affinity FcεRI on mast cells and basophils, IgE orchestrates the rapid activation and mediator release that underlies immediate hypersensitivity reactions. …

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Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation

Mario Pérez-Diego, Alba Angelina, Yağız Pat, Angel E. Maldonado et autres

Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation

Mario Pérez-Diego, Alba Angelina, Yağız Pat, Angel Maldonado et autres

A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease

Carmen Sevilla‐Ortega, Alba Angelina, Leticia Martín‐Cruz, Mario Pérez‐Diego et autres

Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. Here we show MV130 prevents …

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Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation

Mario Pérez‐Diego, Alba Angelina, Yağız Pat, Angel E. Maldonado et autres

BACKGROUND: Viral infections and type 2 immune responses perpetuate airway epithelial barrier dysfunction and inflammation, leading to the development and progression of asthma. The synthetic cannabinoid WIN55,212-2 displays anti-inflammatory properties by acting on different immune system cells. OBJECTIVE: We sought to investigate …

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Die Rolle regulatorischer T-Zellen bei allergischen Erkrankungen: Collegium International Allergologicum (CIA) Update 2024

Leticia Martín‐Cruz, Cristina Benito‐Villalvilla, Sofia Sirventa, Alba Angelina et autres

Hintergrund: Allergien sind ein bedeutendes Gesundheitsproblem mit weltweit steigender Prävalenz und erheblichen sozioökonomischen Auswirkungen. Unser Verständnis der molekularen Mechanismen, die allergischen Erkrankungen und ihrer Behandlung zugrunde liegen, hat sich in den letzten Jahren deutlich verbessert. Die Bildung allergenspezifischer regulatorischer T-Zellen (Tregs) ist …

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The Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3 + Tregs

Andrés de la Rocha‐Muñoz, Cristina Benito‐Villalvilla, David Olivares, Sofía Sirvent et autres

ABSTRACT Background A causal relationship between Crohn's disease (CD) and asthma is reported, but the underlying mechanisms are not fully understood. We sought to investigate the role of IgE and IgE‐mediated pathways in the pathophysiology of CD. Methods 20 CD patients, 10 …

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Trained immunity–based vaccines for infections and allergic diseases

Leticia Martín‐Cruz, Cristina Benito‐Villalvilla, Alba Angelina, José Luis Subiza et autres

Trained immunity has emerged as a new concept in immunology that is associated with the memory of innate immune cells and linked to specific metabolic and epigenetic reprogramming of these cells. Trained immunity may confer nonspecific and sustained protection against a broad …

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Nutritional and environmental exposures in athletes: Implications on the epithelial barrier function

Alba Angelina, Mario Pérez‐Diego, Óscar Palomares

Over the last decades, industrialization, and technological advances associated with a modern lifestyle have been accompanied by an alarming rise in the prevalence of chronic noncommunicable diseases.1 The epithelial barrier theory attributes this phenomenon to exposure to newly introduced toxic substances that …

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Grass pollen allergoids conjugated with mannan for subcutaneous and sublingual immunotherapy: a dose-finding study

Pedro Ojeda, María Concepción Barjau, Javier Subiza, Antonio Moreno et autres

Background: ) administered via either the subcutaneous or sublingual route. Methods: A randomized, double-blind, placebo-controlled trial with a double-dummy design was conducted, involving 162 participants across 12 centers in Spain. Subjects were randomly allocated to one of nine different treatment groups, each …

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