José Luis Subiza

Proteomic profiling of Juniperus oxycedrus and Cupressus arizonica pollen reveals quantitative interspecies differences in the IgE-binding protein repertoire associated with Mediterranean Cupressaceae allergy

Sandra Sivill, José Carlos Hernández-Walias, J Igea, Jose Alejandro Lemus Calderon et autres

Background Diagnosis and allergen-specific immunotherapy for Mediterranean allergy rely on extracts standardized to group-1 allergens, such as Cup a 1 from Cupressus arizonica , potentially overlooking interspecies variability. The native species Juniperus oxycedrus , widespread in Spain, may contribute to sensitization, but …

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Circulating carbohydrate antigen Ca10H predicts favorable prognosis in colorectal cancer

Pablo Mata-Martínez, Laura Bravo-Robles, Laura Hurtado-Navarro, Laura Córdoba et autres

Non-invasive biomarkers for early detection and prognosis of colorectal cancer (CRC) remain an unmet clinical need. In this work, we investigated Ca10H, a novel circulating carbohydrate antigen, as a plasma biomarker with prognostic value in CRC. Plasma Ca10H was quantified by ELISA …

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Short-Course Subcutaneous Immunotherapy with Mannan-Conjugated Birch Pollen Allergoids: Consistent Clinical and Immunological Improvements

E Raskopf, Sofia Passamera, Ludger Klimek, Oliver Pfaar et autres

Background: The mannan-conjugated birch pollen polymerised allergoid EP-088_T502 has previously been shown to reduce allergic symptoms and anti-allergic medication use during the birch pollen season. This confirmatory phase III trial aimed to evaluate the efficacy, safety, tolerability, and immunologic effects of six …

Sustained Clinical Improvement in Birch Pollen Allergy After Two Pre‐Seasonal Short Courses of Allergen‐Specific Immunotherapy: A Long‐Term Open‐Label Extension Study

Ralph Mösges, Friederike Hüffmeier, Ludger Klimek, Oliver Pfaar et autres

BACKGROUND: Mannan-conjugated allergoids represent an effective option for treating allergic diseases. This study evaluated the clinical impact of the mannan-conjugated, polymerised birch pollen allergoid EP-088_T502 in patients with birch pollen-induced allergic rhinoconjunctivitis over 3 years. METHODS: Following up to a double-blind, placebo-controlled …

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Clinical Efficacy of One Short Course of Mannan-Conjugated Birch Pollen Allergoid Immunotherapy: A Comparative Evaluation After Prior Placebo Treatment

Sandra del Pozo, Natascha Wahrhusen, Oliver Pfaar, E Raskopf et autres

Background/Objectives: Allergen immunotherapy (AIT) with chemically modified allergoids represents a promising approach for the treatment of allergic rhinoconjunctivitis. This post hoc analysis investigated the clinical efficacy of a mannan-conjugated birch pollen allergoid (T502) by comparing outcomes in patients who received placebo in …

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Clinical Efficacy of One Short Course of Mannan-Conjugated Birch Pollen Allergoid Immunotherapy: A Comparative Evaluation After Prior Placebo Treatment

Sandra del Pozo, Natascha Wahrhusen, Oliver Pfaar, E Raskopf et autres

Background/Objectives: Allergen immunotherapy (AIT) with chemically modified allergoids represents a promising approach for the treatment of allergic rhinoconjunctivitis. This post-hoc analysis investigated the clinical efficacy of a mannan-conjugated birch pollen allergoid (T502) by comparing outcomes in patients who received placebo in one …

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Peptides Derived from α-Tubulin Induce Functional T Regulatory Cells

Tara Fiyouzi, José Luis Subiza, Esther M. Lafuente, Pedro A. Reche

Regulatory T (Treg) cells are essential for maintaining self-tolerance and regulating immune responses. In this study, we report the identification of Treg cell epitopes in human α-tubulin that were capable of enhancing IL-10-producing Foxp3+ Treg cells and LAG-3+CD49b+FoxP3− Tr1 cells in vitro, …

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A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease

Carmen Sevilla‐Ortega, Alba Angelina, Leticia Martín‐Cruz, Mario Pérez‐Diego et autres

Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. Here we show MV130 prevents …

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Vaccines and adjuvants in allergen specific immunotherapy: current status and future directions

Yiwu Zheng, José Luis Subiza

Allergen specific immunotherapy (AIT) has a history spanning over 110 years and represents the only disease-modifying treatment for allergic diseases, with potential preventive effects. Nevertheless, the broader application of AIT is limited by the inherent drawbacks of natural allergen extracts, such as …

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Polymerised mite allergoids with glutaraldehyde reduce proteolytic activity and enhance the stability of allergen mixtures: a proof of concept with grass mixtures

José Ignacio Tudela, Irene Soria, Eva Abel-Fernández, José Fernando Cantillo et autres

Background: Polysensitized patients require allergen immunotherapy (AIT) targeting multiple allergens. However, combining allergen extracts can lead to instability and reduced efficacy particularly due to the high proteolytic activity of house dust mite (HDM) allergens. While is known that glutaraldehyde cross-linking may reduce …

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Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow

Iñaki Robles‐Vera, Aitor Jarit-Cabanillas, Paola Brandi, María Martínez‐López et autres

mice showed impaired TI upon E. faecalis administration and reduced pathology following DSS treatment. Thus, Mincle sensing of E. faecalis induces TI that may have long-term effects on pathologies associated with increased gut permeability.

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Treg cell epitopes from α -tubulin: discovery and immunomodulatory features

Tara Fiyouzi, José Luis Subiza, Esther M. Lafuente, Pedro A. Reche

Abstract Regulatory T (Treg) cells are pivotal in maintaining self-tolerance and controlling immune responses. In this study, we investigated potential Treg cell epitopes in human α-tubulin that were selected in silico for their promiscuous binding to class II human leukocyte antigens and …

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