Tie‐Mei Li

Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor

Melissa V. R. Gammons, Elsa Franco-Echevarría, Tie‐Mei Li, Trevor J. Rutherford et autres

Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic resonance spectroscopy to identify the membrane-proximal PPPSPxS …

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Mammalian SIRT6 Represses Invasive Cancer Cell Phenotypes through ATP Citrate Lyase (ACLY)-Dependent Histone Acetylation

Wei Zheng, Luisa Tasselli, Tie‐Mei Li, Katrin F. Chua

The modulation of dynamic histone acetylation states is key for organizing chromatin structure and modulating gene expression and is regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. The mammalian SIRT6 protein, a member of the Class III HDAC Sirtuin family …

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Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation

Peggie Cheung, Steven A. Schaffert, Sarah Esther Chang, Mai Dvorak et autres

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Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation

Tie‐Mei Li, Jing Ren, Dylan Husmann, John P. Coan et autres

The tumor suppressor adenomatous polyposis coli (APC) is frequently mutated in colorectal cancers. APC and Axin are core components of a destruction complex that scaffolds GSK3β and CK1 to earmark β-catenin for proteosomal degradation. Disruption of APC results in pathologic stabilization of …

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Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue

Muhammad Zoabi, Lichao Zhang, Tie‐Mei Li, Joshua Eric Elias et autres

Protein-lysine methylation is a common posttranslational modification (PTM) throughout the human proteome that plays important roles in diverse biological processes. In humans, there are >100 known and candidate protein lysine methyltransferases (PKMTs), many of which are linked to human diseases. Methyltransferase-like protein …

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

Zhentian Wang, Simone Hausmann, Ruitu Lyu, Tie‐Mei Li et autres

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Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules

Tie‐Mei Li, John P. Coan, Krzysztof Krajewski, Lichao Zhang et autres

Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization. While the YEATS domain has been found to be a prominent reader of acetylation and other short acyl …

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SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Alex W. Wilkinson, Jonathan Diep, Shaobo Dai, Shuo Liu et autres

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The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

Silvana Paredes, Maria Angulo‐Ibáñez, Luisa Tasselli, Scott M. Carlson et autres

, genomic instability in rDNA repeat sequences is an underlying cause of cell aging and is suppressed by the chromatin-silencing factor Sir2. In humans, rDNA instability is observed in cancers and premature aging syndromes, but its underlying mechanisms and functional consequences remain …

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Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

Weikang You, Dante Rotili, Tie‐Mei Li, Christian Kambach et autres

Sirtuins are protein deacylases regulating metabolism and stress responses, and are implicated in aging-related diseases. Small molecule activators for the human sirtuins Sirt1-7 are sought as chemical tools and potential therapeutics, such as for cancer. Activators are available for Sirt1 and exploit …

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Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

Weikang You, Dante Rotili, Tie‐Mei Li, Christian Kambach et autres

Abstract Sirtuins are protein deacylases regulating metabolism and stress responses, and are implicated in aging‐related diseases. Small molecule activators for the human sirtuins Sirt1‐7 are sought as chemical tools and potential therapeutics, such as for cancer. Activators are available for Sirt1 and …

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Quantitative Proteomics of Sleep-Deprived Mouse Brains Reveals Global Changes in Mitochondrial Proteins

Jing Ren, Meijun Zhang, Tie‐Mei Li, Ju-en Zhang et autres

Sleep is a ubiquitous, tightly regulated, and evolutionarily conserved behavior observed in almost all animals. Prolonged sleep deprivation can be fatal, indicating that sleep is a physiological necessity. However, little is known about its core function. To gain insight into this mystery, …

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