Accès ouvert
2024
article
OpenAlex
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces et autres
Abstract Telomerase is intimately associated with stem cells and cancer, because it catalytically elongates telomeres—nucleoprotein caps that protect chromosome ends1. Overexpression of telomerase reverse transcriptase (TERT) enhances the proliferation of cells in a telomere-independent manner2–8, but so far, loss-of-function studies have provided …
us
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Accès ouvert
2023
article
OpenAlex
Samantha Slight‐Webb, Kevin L. Thomas, Miles Smith, Catriona A. Wagner et autres
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomics …
us, jp, ca
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Lawrence Bai, Denis Đermadi, Laurynas Kalesinskas, Mai Dvorak et autres
BACKGROUND AND AIMS: Current understanding of histone post-translational modifications [histone modifications] across immune cell types in patients with inflammatory bowel disease [IBD] during remission and flare is limited. The present study aimed to quantify histone modifications at a single-cell resolution in IBD …
us
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Accès ouvert
2022
preprint
OpenAlex
Denis Đermadi, Laurynas Kalesinskas, Ananthakrishnan Ganesan, Alex Kuo et autres
ABSTRACT Chromatin remodeling through post-translational modifications of histone tails (HPTM) is fundamental for regulation and maintenance of DNA-centered processes. Systems level understanding of coordination and interactions between HPTMs and their impact on the functional state of the immune cells remain unexplored due …
us, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Samantha Slight‐Webb, Kevin Thomas, Miles Smith, Susan Macwana et autres
us
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Accès ouvert
2021
article
OpenAlex
Sarah E. Chang, Allan Feng, Wenzhao Meng, Sokratis A. Apostolidis et autres
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, and anti-viral antibody responses in serum from 147 hospitalized …
us, de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Florian Wimmers, Michele Donato, Alex Kuo, Tal Ashuach et autres
us, be
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Florian Wimmers, Michele Donato, Alex Kuo, Tal Ashuach et autres
Abstract Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we used a systems biology approach to map the epigenomic and transcriptional landscape of immunity to influenza vaccination in humans at the single-cell level. Vaccination against seasonal influenza resulted …
us, be
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Peggie Cheung, Steven Schaffert, Sarah E. Chang, Mai Dvorak et autres
us, ca
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces et autres
Summary Telomerase is intimately associated with stem cells and upregulated in cancer, where it serves essential roles through its catalytic action in elongating telomeres, nucleoprotein caps that protect chromosome ends 1 . Overexpression of the telomerase reverse transcriptase (TERT) enhances cell proliferation …
us
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Sarah E. Chang, Allan Feng, Wenzhao Meng, Sokratis A. Apostolidis et autres
Abstract Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. We developed three different protein arrays to measure hallmark IgG autoantibodies associated with Connective …
us, de
(code pays fourni par la source)
Accès ouvert
2019
review
OpenAlex
Peggie Cheung, Purvesh Khatri, Paul J. Utz, Alex Kuo
us
(code pays fourni par la source)