Natalia Soledad Tissera

Ultra-refractory PD–PD pancreatic cancer: Clinical and molecular insights across first- and second-line therapy.

Natalia Soledad Tissera, Sharela Vega, José María Ucha, Sofía Llorente et autres

4206 Background: A subset of pancreatic cancer (PC) patients exhibits progressive disease (PD) as the best response to both first- and second-line chemotherapy (PD-PD), representing an ultra-refractory population with dismal outcomes. This group remains poorly characterized, highlighting a critical unmet need for …

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The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer

Carl-Stephan Leonhardt, Mustapha Adham, Shouki N. Bazarbashi, Irit Ben-Aharon et autres

at, sa, il, nl, it, ch, fr, us, be, gb, de, es, kr, cy, dk, mx, jp, in, au (code pays fourni par la source)

Clinical implications of multiple co-occurring targetable alterations in biliary tract cancers

Virginia Genovesi, Florian Castet, Sharela Vega, Francesca Salani et autres

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380eP Perineural invasion is a prognostic factor in cholangiocarcinoma, regardless of anatomical location: A systematic review and meta-analysis

Natalia Soledad Tissera, Serenella Conti, Florian Castet, Míriam Basagaña-Farrés et autres

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300P Clinical, pathological, and genomic biomarkers associated with early recurrence in resected localized pancreatic ductal adenocarcinoma (L-PDAC)

Virginia Genovesi, Natalia Soledad Tissera, Anthony Turpin, Florian Castet et autres

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Maintenance therapy after first-line platinum-based chemotherapy in gastroenteropancreatic neuroendocrine carcinomas: A literature review

Natalia Soledad Tissera, Francesca Balconi, Alejandro García‐Álvarez, Jorge Hernando Cubero et autres

Neuroendocrine carcinomas are rare and aggressive malignancies, often diagnosed at advanced stages, leading to poor prognosis. Platinum-based chemotherapy is the standard first-line treatment for advanced neuroendocrine carcinomas; however after achieving response no consensus exists on maintenance therapies and the results are inconsistent. …

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Efficacy of First-Line Nivolumab Plus Ipilimumab in Unresectable Pleural Mesothelioma: A Multicenter Real-World Study (ImmunoMeso LATAM)

Diego Hernán Enrico, J. Gomez, Danilo Aguirre, Natalia Soledad Tissera et autres

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Abstract 519: Targeting MYC as a novel therapeutic strategy for an epigenetic-driven cancer: NUT Carcinoma

Carmen Escudero‐Iriarte, Joel Castro, Iker Beniavides-Puy, Natalia Soledad Tissera et autres

Abstract Epigenetic dysregulation is widespread in cancer, playing a pivotal role in shaping cell function and contributing to the process of oncogenic transformation. NUT Carcinoma (NC) is an exceptionally rare and aggressive cancer lacking effective treatment, with a dismal prognosis - NC …

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LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres

Oxidation of histone H3 at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase homolog 2 (LOXL2). This histone modification is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells and has been linked to the maintenance of compacted chromatin. However, the molecular …

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Author response for " LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells"

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres

Clinical and genomic characterization of pancreatic ductal adenocarcinoma patients with lung oligometastasis

Natalia Soledad Tissera, Marta Chiaravalli, Anthony Turpin, Romina Luca et autres

Lung-only relapse following resection of pancreatic ductal adenocarcinoma (PDAC) is rare. While oligometastatic lung disease (OMLD) is detected after PDAC resection, its clinical and molecular features remain unclear. Our goal was to assess if lung metastatic lesion quantity and mutations could predict …

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Author response for " LOXL 2‐mediated chromatin compaction is required to maintain the oncogenic properties of triple‐negative breast cancer cells"

Gemma Serra‐Bardenys, Enrique Blanco, Carmen Escudero‐Iriarte, Queralt Serra‐Camprubí et autres