Shisheng Chen

Clinical Characteristics of Granular Parakeratosis Caused by Benzalkonium Chloride: A Retrospective Case Series

Fan Lin, Yingwei Wang, Shisheng Chen

Background: Granular parakeratosis (GP) is a rare keratinization disorder. Recent studies have suggested a possible association with exogenous irritants such as benzalkonium chloride (BAK); however, the clinical features of related cases have not yet been systematically characterized. Aim: To analyze the clinical …

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Simultaneous targeting of multiple etiological using a nanosized strategy for psoriasis management

Xinyu Jiang, Minghui Wang, Linyi Zhang, Pengfei Mao et autres

Psoriasis is an inflammatory skin disease influenced by the immune system, with a notable tendency to recurrence, characterized by irregular keratinocyte multiplication, presence of inflammatory cells, excessive secretion of pro-inflammatory chemicals, and abnormal blood vessel proliferation. Even though the detailed pathogenesis of …

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A bioadhesive sustained-release films for in situ therapy of oral ulcers

Hongping Ge, Jing Yu, Pan Li, Lifang Zhang et autres

A multifunctional adhesive electrospun BG/HPMC film delivers BG-derived bioactive ions (Si, Ca, Na, P) to the oral ulcer site, creating a biomimetic microenvironment. This enables synergistic antimicrobial, pro-proliferative (epithelial/endothelial), ROS-scavenging, and anti-inflammatory effects, accelerating ulcer re-epithelialization. The study demonstrates the effectiveness of …

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A Low-Friction Capsule Robot with Drive–Control–Sensing Integration for Gastrointestinal Lesion Detection

Ziying Wang, Zilin Wei, Shisheng Chen, Jiameng Li et autres

pH and temperature in the gastrointestinal (GI) tract are correlated with many diseases, but patients suffer from the pain of traditional testing methods. Functionalized capsule robots for GI tract sensing offer a potential approach for early GI disease diagnosis. However, most capsule …

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A Body‐Temperature‐Triggered In Situ Softening Peripheral Nerve Electrode for Chronic Robust Neuromodulation

Xueyang Ren, Wenjie Tang, Yuehui Yuan, Shisheng Chen et autres

Abstract Implantable peripheral nerve electrodes are crucial for monitoring health and alleviating symptoms of chronic diseases. Advanced compliant electrodes have been developed because of their biomechanical compatibility. However, these mechanically tissue‐like electrodes suffer from unmanageable operating forces, leading to high risks of …

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Uniaxial extending neural probes for bleeding-absent implantation

Xueyang Ren, Wen Jing Bai, Shisheng Chen, Yuehui Yuan et autres

Abstract Implantable neural probes, essential for brain electrophysiological research, have advanced with ultra-flexible designs to mitigate immune responses and postoperative complications. Strategies of shuttle-assisted implantation and temporary stiffening address issues in penetrating these probes into the target region, avoiding undesired bending. However, …

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Ultralow-cost piezoelectric sensor constructed by thermal compression bonding for long-term biomechanical signal monitoring in chronic mental disorders

Xiaodong Shao, Zenan Chen, Junxiao Yu, Fangzhou Lu et autres

), rapid response (8 ms), and exceptional stability over 2000 compression/release cycles, all at a negligibly low fabrication cost. We demonstrate that pulse wave, blink, and speech signals can be acquired by the sensor, proposing a single biomechanical modality to monitor multiple …

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In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Shisheng Chen, Xueyang Ren, Jingfeng Xu, Yuehui Yuan et autres

A tactile sensor needs to perceive static pressures and dynamic forces in real-time with high accuracy for early diagnosis of diseases and development of intelligent medical prosthetics. However, biomechanical and external mechanical signals are always aliased (including variable physiological and pathological events …

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Author Correction: A chemically mediated artificial neuron

Ting Wang, Ming Wang, Jianwu Wang, Le Yang et autres

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A chemically mediated artificial neuron

Ting Wang, Ming Wang, Jianwu Wang, Le Yang et autres

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Minimally-invasive and non-invasive flexible devices for robust characterizations of deep tissues

Yuehui Yuan, Wenjie Tang, Hao Wu, Shisheng Chen et autres

Deep-tissue signals often have a strong correlation with disease. Clinical detection and diagnosis of deep tissue mostly rely on large-scale instruments such as medical imaging equipment, which is costly and not conducive to long-term monitoring. Different from bulky and large-scale equipment, minimally …

Stress-deconcentrated ultrasensitive strain sensor with hydrogen-bonding-tuned fracture resilience for robust biomechanical monitoring

Wenjie Tang, Jinyi Wang, Ruiqing Liu, Ping Yang et autres

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