Juliane Kohlen

Entwicklung einer schnellen standardisierten Phagenspezifitätstestung für diagnostische Routinelabore in Anlehnung an die Plättchen-basierte Agardiffusionstestung

Juliane Kohlen

Aufgrund der Zunahme antimikrobieller Resistenzen erfährt die Therapie mit Bakteriophagen eine Renaissance. Bisherige Phagenspezifitätstestungen wie Spottest und Double Agar Overlay Assay erfolgen nicht standardisiert. Im Rahmen einer Machbarkeitsstudie konnte in dieser Arbeit eine Phagenspezifitätstestung in Anlehnung an die Plättchen-basierte Agardiffusionstestung entwickelt werden, …

Introducing “Rapid phage susceptibility testing” (RPST): an accelerated lytic phage activity test for routine diagnostic laboratories within eight hours

Romy Skusa, Juliane Kohlen, Andreas Podbielski, Philipp Warnke

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Proof-of-Concept Standardized Approach Using a Single-Disk Method Analogous to Antibiotic Disk Diffusion Assays for Routine Phage Susceptibility Testing in Diagnostic Laboratories

Romy Skusa, Justus Groß, Juliane Kohlen, Clemens Schafmayer et autres

Application of bacteriophages in clinical therapies is attractive due to increasing rates of isolation of multidrug-resistant bacteria worldwide. As the phage effect is highly specific, prior susceptibility testing of target bacteria is mandatory. Of note, established standards are lacking. In this research, …

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Bacteriophages for the Treatment of Graft Infections in Cardiovascular Medicine

Simon Junghans, Sebastián V. Rojas, Romy Skusa, Anja Püschel et autres

Bacterial infections of vascular grafts represent a major burden in cardiovascular medicine, which is related to an increase in morbidity and mortality. Different factors that are associated with this medical field such as patient frailty, biofilm formation, or immunosuppression negatively influence antibiotic …

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Treatment Complexity in Primary Open-Angle Glaucoma (POAG): Perspectives on Patient Selection in Micro-Invasive Glaucoma Surgery (MIGS) Using Stents

Christian Helbig, Anja Wollny, Attila Altiner, Annette Diener et autres

BACKGROUND: Primary open-angle glaucoma (POAG) is still one of the most common causes of impaired vision worldwide, despite the further development of therapy options, and can lead to blindness. Micro-invasive glaucoma surgery (MIGS) using stents aims at reducing intraocular pressure (IOP), as …