Annette Diener

Patterns and Facilitators for the Promotion of Glaucoma Medication Adherence—A Qualitative Study

Stefanie Frech, Rudolf Friedrich Guthoff, Amin Gamael, Christian Helbig et autres

Primary open-angle glaucoma (POAG) is a chronic optic neuropathy causing irreversible nerve fiber damage. Initially asymptomatic, it progresses slowly without any notable sign of vision loss, thus early detection and treatment is essential. The standard treatment being non-invasive topical administration of eye …

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Treatment Complexity in Primary Open-Angle Glaucoma (POAG): Perspectives on Patient Selection in Micro-Invasive Glaucoma Surgery (MIGS) Using Stents

Christian Helbig, Anja Wollny, Attila Altiner, Annette Diener et autres

BACKGROUND: Primary open-angle glaucoma (POAG) is still one of the most common causes of impaired vision worldwide, despite the further development of therapy options, and can lead to blindness. Micro-invasive glaucoma surgery (MIGS) using stents aims at reducing intraocular pressure (IOP), as …

Hospitalization for Acute Respiratory Tract Infection in a Low-Antibiotic-Prescribing Setting: Cross-Sectional Data from General Practice

Christin Löffler, Attila Altiner, Annette Diener, Reinhard Berner et autres

BACKGROUND: Acute respiratory tract infections (ARTI) are the main cause of inappropriate antibiotic prescribing. To date, there is limited evidence concerning whether low levels of antibiotic prescribing may impact patient safety. We investigate whether antibiotic prescribing for patients seeking primary care for …

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In-vivo-validation of a cardiovascular risk prediction tool: the arriba-pro study

Annette Diener, Salomé Celemín-Heinrich, Karl Wegscheider, Kai Kolpatzik et autres

BACKGROUND: Calculation of individual risk is the cornerstone of effective cardiovascular prevention. arriba is a software to estimate the individual risk to suffer a cardiovascular event in 10 years. Prognosis and the absolute effects of pharmacological and lifestyle interventions help the patient …

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Converting habits of antibiotic prescribing for respiratory tract infections in German primary care – the cluster-randomized controlled CHANGE-2 trial

Attila Altiner, Reinhard Berner, Annette Diener, Gregor Feldmeier et autres

BACKGROUND: With an average prescription rate of 50%, in German primary care antibiotics are still too frequently prescribed for respiratory tract infections. The over-prescription of antibiotics is often explained by perceived patient pressure and fears of a complicated disease progression. The CHANGE-2 …

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The Influence on Cell Growth Properties in Different Microtiterplate Types by Corona‐Dielectric Barrier Discharge Plasma at Atmospheric Pressure

Marcel Hähnel, Annette Diener, Üner Kolukisaoglu, Klaus‐Dieter Weltmann et autres

Abstract In high throughput processes with living cells maintenance of sterility is a cost‐intensive but essential requirement. In the course of this work an atmospheric plasma process was developed for the sterilization of microtiterplates in such assays. In a next step it …

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Inhibitory effects of phthalimide derivatives on the activity of the hepatic cytochrome P450 monooxygenases CYP2C9 and CYP2C19

Üner Kolukisaoglu, Christian Wendler, Dirk Goerdes, Annette Diener et autres

Affecting hepatic cytochrome (CYP) activity is one of the major concerns in drug-drug interaction. Thus the testing of drug candidates on their impact on these enzymes is an essential step in early drug discovery. We tested a collection of 480 in-house phthalimide …

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Similarities between Plasma Amino Functionalized PEEK and Titanium Surfaces Concerning Enhancement of Osteoblast Cell Adhesion

Karsten Schröder, Birgit Finke, Henrike Jesswein, Frank Lüthen et autres

The application of gas discharge plasmas for different functionalization and coating strategies is discussed with respect to cell adhesion to polymeric and metallic surfaces. Poly(ether ether ketone) (PEEK) and titanium (Ti) were selected as typical bone cell-contacting biomaterials. The surfaces were equipped …

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Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells

Petra Müller, Ulrike Bulnheim, Annette Diener, Frank Lüthen et autres

Although studies in vivo revealed promising results in bone regeneration after implantation of scaffolds together with osteogenic progenitor cells, basic questions remain how material surfaces control the biology of mesenchymal stem cells (MSC). We used human MSC derived from bone marrow and …

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Control of focal adhesion dynamics by material surface characteristics

Annette Diener, Barbara Nebe, Frank Lüthen, Petra Becker et autres

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Effects of Titanium Surface Topography on the Cell-Extracellular Matrix Interaction in Osteoblasts

Barbara Nebe, Frank Lüthen, Axel Baumann, Ulrich Beck et autres

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Unusual Structural Properties of a Complex of Calmodulin with a Binding Peptide of the Ca2+-Pump: A NMR Study.

Bettina Elshorst, Michael Hennig, H. Foersterling, Annette Diener et autres

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