Shiao‐Ya Hong

Inflammatory Gene Expression, Insulin Resistance, and Circulating Markers Vary by Visceral Adiposity in Patients with Metabolic Dysfunction–Associated Steatotic Liver Disease

Yi-Hsuan Lin, Chia-Chen Ma, S. H. Tsai, Shiao‐Ya Hong et autres

Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is driven by complex immune and inflammatory mechanisms. Visceral adiposity, a key contributor, worsens inflammation, immune dysregulation, and insulin resistance. Objective: This study examines correlations between inflammatory genes, insulin resistance markers, and inflammatory markers across …

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Microbial Consortia-Immunoglobulin G Glycosylation Combination Scores Identify Severe Hepatic Steatosis and Significant Fibrosis in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

Tzu‐Hao Li, Chao Ma, Jhen‐Wei Ruan, Shin‐Yu Tsai et autres

INTRODUCTION: Severe hepatic steatosis (HS) and significant hepatic fibrosis indicate severity of metabolic dysfunction-associated steatotic liver disease (MASLD), and the models for early detection are important. Recent studies suggest immunoglobulin G (IgG) glycosylation and microbial consortia may involve in the development of …

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Increased risk of acute exacerbation in obstructive airway disease: the impact of metabolic dysfunction-associated steatotic liver disease and small airway dysfunction

Che-Hao Tseng, Bor-Yang Jou, Hsiao‐Chin Shen, Hsiao-Yun Yeh et autres

BACKGROUND AND STUDY AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolic and liver condition that leads to systemic inflammation. Obstructive airway diseases (OADs) are characterised by chronic airway inflammation, with small airway dysfunction (SAD) regarded as an early indicator. …

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Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity

Wan‐Hsuan Chou, Che‐Mai Chang, Jafit Ting, Min‐Rou Lin et autres

Background Research comprehensively examining factors for COVID-19 DNA vaccine responses is lacking, particularly in Asian populations. This study aims to investigate biomarkers of reactogenic and immunogenic responses after DNA-based COVID-19 vaccination in a Taiwanese population. Methods A genome-wide association study (GWAS) of …

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Cabozantinib Sensitizes NSCLC Cells to Radiation by Inducing Ferroptosis via STAT3/MCL1/BECN1/SLC7A11 Axis Suppression

Cheng‐Yi Wang, Chao‐Yuan Huang, Li‐Ju Chen, Shiao‐Ya Hong

Background/Objectives: Intrinsic radioresistance in non-small-cell lung cancer (NSCLC) is partially driven by adaptive redox mechanisms that prevent oxidative cell death. Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, has emerged as a potential therapeutic vulnerability in tumors with …

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Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan

Hsiao‐Yun Yeh, Mei‐Hung Pan, Chih-Jen Huang, Shiao‐Ya Hong et autres

BACKGROUND: Insulin resistance (IR) is a key metabolic abnormality associated with adverse health outcomes, including increased cancer risk. The triglyceride-glucose (TyG) index, a validated surrogate marker of IR, has been linked to metabolic dysfunction; however, its association with cancer risk in large …

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GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non‐Obese Patients With MASLD and Hyperuricemia

Tzu‐Hao Li, Chao Ma, Shin‐Yu Tsai, Hung‐Cheng Tsai et autres

Metabolic-associated steatotic liver disease (MASLD) encompasses common comorbidities including low bone mineral density (BMD) and hyperuricemia (HU), yet relevant genetic analyses are limited. This study aimed to investigate the genetic effects of risk single nucleotide polymorphisms (SNPs) on the occurrence of low …

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Author response for "Protective effects of statins on pulmonary function in patients with persistent hyperlipidemia: a retrospective cohort study"

Hsiao‐Chin Shen, Yi-Hsuan Lin, Hsiao-Yun Yeh, Hung‐Cheng Tsai et autres

Protective effects of statins on pulmonary function in patients with persistent hyperlipidemia: a retrospective cohort study

Hsiao‐Chin Shen, Yi-Hsuan Lin, Hsiao-Yun Yeh, Hung‐Cheng Tsai et autres

BACKGROUND: Pulmonary function tests offer crucial parameters for evaluating lung health and predicting clinical outcomes. Hyperlipidemia, a prevalent metabolic disorder, has been linked to declining pulmonary function. Statins are an essential therapy for lowering lipid levels in hyperlipidemia. OBJECTIVES: This study aims …

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Author response for "Protective effects of statins on pulmonary function in patients with persistent hyperlipidemia: a retrospective cohort study"

Hsiao‐Chin Shen, Yi-Hsuan Lin, Hsiao-Yun Yeh, Hung‐Cheng Tsai et autres

Enhanced radiotherapy susceptibility in NSCLC through palbociclib-mediated PP5 inhibition

Chao‐Yuan Huang, Li‐Ju Chen, Grace L. Chen, Shiao‐Ya Hong

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MCL1 inhibition: a promising approach to augment the efficacy of sorafenib in NSCLC through ferroptosis induction

Chao‐Yuan Huang, Li‐Ju Chen, Chi‐Shuo Chen, Cheng‐Yi Wang et autres

Abstract Ferroptosis, an iron-dependent form of regulated cell death, plays a crucial role in modulating the therapeutic response in non-small cell lung cancer (NSCLC) patients. Studies have identified the signal transducer and activator of transcription 3 (STAT3) and myeloid cell leukemia-1 (MCL1) …

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