Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan
Rattachement africain : tw, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Insulin resistance (IR) is a key metabolic abnormality associated with adverse health outcomes, including increased cancer risk. The triglyceride-glucose (TyG) index, a validated surrogate marker of IR, has been linked to metabolic dysfunction; however, its association with cancer risk in large population-based cohorts remains unclear. This study aimed to evaluate the relationship between TyG index and cancer risk in Taiwanese population. METHODS: We analyzed 150,592 participants from the Taiwan Biobank, among whom 148,809 were linked to the Taiwan Cancer Registry (2011-2022) for cancer incidence tracking. Cancer risk was assessed across TyG quartiles over a median follow-up of 5.7 years (IQR: 3.4-7.6). Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for key covariates. RESULTS: Higher TyG index levels were associated with increased risks of digestive system cancer (adjusted HR [aHR]: 1.17, 95% CI: 1.05-1.29), colorectal cancer (aHR: 1.25, 95% CI: 1.08-1.44), and urinary tract cancer (aHR: 1.47, 95% CI: 1.18-1.85). While subgroup trends suggested numerically higher risks in males, individuals aged ≥ 50 years, and those with overweight or obesity for these cancer types, formal interaction tests did not support statistically significant effect modification in these groups. Significant interactions were observed for overall cancers by age (P < 0.001) and BMI (P = 0.012), and for urinary tract cancer by drinking status (P = 0.047). In a subset of 19,808 participants with follow-up data, higher TyG quartiles were also linked to fatty liver, carotid plaques, and persistent IR over time (r = 0.75). CONCLUSIONS: Higher TyG index levels, indicative of greater IR, are associated with an elevated risk of digestive system, colorectal, and urinary tract cancers. Evaluating TyG index levels could assist in risk stratification for these cancers among individuals with persistent IR, supporting targeted prevention strategies.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan
- Date Crossref
- 18/07/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Yang Ming Chiao Tung University Department of Biotechnology and Laboratory Science in Medicine pays non établi dans la noticeUniversité ou école supérieure
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Taipei Veterans General Hospital Department of Family Medicine pays non établi dans la noticeÉtablissement de santé
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Genomics Research Center pays non établi dans la noticeStructure de recherche
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Kaohsiung Medical University pays non établi dans la noticeUniversité ou école supérieure
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China Medical University Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Institute of Biomedical Sciences pays non établi dans la noticeStructure de recherche
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Fu Jen Catholic University pays non établi dans la noticeUniversité ou école supérieure
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Memorial Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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School of medicine pays non établi dans la noticeUniversité ou école supérieure
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Biomedical Translation Research Center pays non établi dans la noticeStructure de recherche
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College of Medicine Graduate Institute of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Biotechnology and Laboratory Science in Medicine — National Yang Ming Chiao Tung University, Department of Family Medicine — Taipei Veterans General Hospital et Genomics Research Center, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.