Hsiao‐Chin Shen

An Underrecognized Cause of Recurrent Spontaneous Pneumothorax: Birt‐Hogg‐Dubé Syndrome With Isolated Pulmonary Manifestation

Chia-Ni Liu, Hsiao‐Chin Shen, Yi‐Chen Yeh

Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder characterized by a classic triad of cutaneous fibrofolliculomas, bilateral pulmonary cysts and renal tumours. Pulmonary manifestations may occur in isolation, posing a significant diagnostic challenge. We report a 50-year-old non-smoking woman with recurrent …

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Hierarchical analysis of metabolic phenotype reveals distinct microbiota and circulatory transcriptome in metabolic dysfunction–associated steatotic liver disease

Chien-Yi Tung, Yi‐Hsuan Lin, Ya-Yuan Chang, Jhen‐Wei Ruan et autres

AIM: To investigate how visceral adiposity and insulin resistance, defined respectively by visceral adiposity index (VAI) and triglyceride-glucose (TyG) index, jointly influence gut microbiota composition and immune transcriptomes in metabolic dysfunction-associated steatotic liver disease (MASLD), and to explore potential mechanistic pathways. METHODS: …

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Disulfiram Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis with Reduced Endothelial Pyroptosis and Neutrophil Adhesion

Chuan-Yen Sun, Wan‐Ling Yang, Hsiao‐Chin Shen, Wen-Kuang Yu et autres

Objective: Pulmonary fibrosis is a progressive disease characterized by chronic inflammation and ultimately leads to irreversible scarring of lung tissue. Current therapies primarily target fibrotic pathways, such as the antifibrotic agents nintedanib and pirfenidone. In bleomycin-induced lung fibrosis models, neutrophils are critical …

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Efficacy of CPAP Therapy on Liver Steatosis and Insulin Resistance in Fatty Liver Patients With Obstructive Sleep Apnea: A 4‐Year Follow‐Up Cohort Study

Hsiao‐Chin Shen, Yen-Hsun Huang, Tzu‐Hao Li, Chih-Hsun Wu et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA) are comorbid conditions that synergistically increase cardiovascular risk through systemic inflammation and insulin resistance. While continuous positive airway pressure (CPAP) is the standard treatment for OSA, its efficacy in improving hepatic …

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Wearable Eye-Tracking Metrics From Smart Glasses for Cognitive Assessment: A Prospective Digital Health Study (Preprint)

Beau Bo-Sheng Chuang, Tzu-Wei Tseng, Po-Wei Sung, Hsiao‐Chin Shen et autres

BACKGROUND Reading performance is closely associated with cognitive function, and eye-tracking metrics have emerged as sensitive, non-invasive indicators of cognitive processes. Recent advances in wearable technologies, such as smart glasses, enable continuous and scalable measurement of eye movements in real-world settings. However, …

[Application of Evidence-Based Healthcare in Clinical Translation: An Interdisciplinary Collaboration Experience].

S.J Lin, Hao-Min Cheng, Jen-Feng Liang, Teh‐Fu Hsu et autres

This article was written to describe the authors' interprofessional collaboration experience with regard to the clinical translation of evidence-based healthcare. Building upon the spirit of evidence-based medicine invoked at the founding of the Cochrane Centre at Oxford University under the United Kingdom's …

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Inflammatory Gene Expression, Insulin Resistance, and Circulating Markers Vary by Visceral Adiposity in Patients with Metabolic Dysfunction–Associated Steatotic Liver Disease

Yi-Hsuan Lin, Chia-Chen Ma, S. H. Tsai, Shiao‐Ya Hong et autres

Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) is driven by complex immune and inflammatory mechanisms. Visceral adiposity, a key contributor, worsens inflammation, immune dysregulation, and insulin resistance. Objective: This study examines correlations between inflammatory genes, insulin resistance markers, and inflammatory markers across …

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Bisphosphonate-Associated Ocular Adverse Events with an Emphasis on Uveitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

T TSENG, Chuan-Yu Yu, Chun‐Yao Huang, Hsiao‐Chin Shen et autres

PURPOSE: This study aims to investigate the risk of developing ocular adverse events, including uveitis, with bisphosphonate use and to analyze the factors that may lead to higher risks of developing the symptoms. MATERIALS & METHODS: A systematic search was conducted across …

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Augmented Reality-Based In-Hospital Pulmonary Rehabilitation in Individuals With Advanced Lung Cancer to Improve Muscle Strength, Function, and Reduce Respiratory Distress

Wan-Ting Chu, Ching-Hui Wang, Jui-Yuan Su, Jen-Ting Lee et autres

Background: Pulmonary rehabilitation (PR) can improve muscle strength and balance in individuals with advanced lung cancer. Typically, exercise instructions are provided through brochures; however, these lack engagement. Augmented reality (AR) applications can integrate users into digital interfaces, potentially increasing their motivation to …

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Microbial Consortia-Immunoglobulin G Glycosylation Combination Scores Identify Severe Hepatic Steatosis and Significant Fibrosis in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

Tzu‐Hao Li, Chao Ma, Jhen‐Wei Ruan, Shin‐Yu Tsai et autres

INTRODUCTION: Severe hepatic steatosis (HS) and significant hepatic fibrosis indicate severity of metabolic dysfunction-associated steatotic liver disease (MASLD), and the models for early detection are important. Recent studies suggest immunoglobulin G (IgG) glycosylation and microbial consortia may involve in the development of …

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Increased risk of acute exacerbation in obstructive airway disease: the impact of metabolic dysfunction-associated steatotic liver disease and small airway dysfunction

Che-Hao Tseng, Bor-Yang Jou, Hsiao‐Chin Shen, Hsiao-Yun Yeh et autres

BACKGROUND AND STUDY AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolic and liver condition that leads to systemic inflammation. Obstructive airway diseases (OADs) are characterised by chronic airway inflammation, with small airway dysfunction (SAD) regarded as an early indicator. …

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Effect of training content and environmental factors on resident retention rates in postgraduate year programs

Hsiao‐Chin Shen, Pei‐Chi Huang, Mei-Lien Pan, Ching-Wen Yang et autres

BACKGROUND: Talent cultivation is a crucial focus in medical education, and retaining young physicians for further training is a primary goal for major hospitals. This study aimed to identify factors related to postgraduate year (PGY) training that influence the retention rates of …

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