Alison Ardrey

Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of Mycobacterium tuberculosis Displaying Enhanced Metabolic Stability

Nada Mosallam, Paul M. O’Neill, Monika Lisauskaitė, Christopher M. Woodley et autres

High Resolution Image Download MS PowerPoint Slide Squaramides (SQA) were reported as potent antituberculosis drugs through inhibition of the mycobacterial enzyme adenosine triphosphate (ATP) synthase, which is critical for ATP synthesis. However, squaramide compounds showed high metabolic clearance (CL) despite their promising …

gb, us, in, nl (code pays fourni par la source)

Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis

Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer et autres

as a combination strategy to improve therapeutic and pharmacokinetic/pharmacodynamic (PK/PD) indices related to efficacy.

gb, us (code pays fourni par la source)

Remdesivir–ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2

Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H Caygill et autres

A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to increase the therapeutic index of drugs and …

gb (code pays fourni par la source)

Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2

Laura N. Jeffreys, Shaun H. Pennington, Jack Duggan, Claire H Caygill et autres

ABSTRACT A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy, the potential to increase the therapeutic index …

gb (code pays fourni par la source)

Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model

Celina Jin, Malick M. Gibani, Shaun H. Pennington, Xinxue Liu et autres

BACKGROUND: The treatment of enteric fever is complicated by the emergence of antimicrobial resistant Salmonella Typhi. Azithromycin is commonly used for first-line treatment of uncomplicated enteric fever, but the response to treatment may be sub-optimal in some patient groups when compared with …

gb, jp, Malawi (code pays fourni par la source)

Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis

Samantha Donnellan, Ghaith Aljayyoussi, Emmanuel Moyo, Alison Ardrey et autres

Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates based on their predicted clinical efficacy is vital to accelerate the pipeline of new therapies. Recent failures of …

gb (code pays fourni par la source)

Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid

Ana Requena‐Méndez, Geraint Davies, David Michael Waterhouse, Alison Ardrey et autres

Background: Poor response to TB therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic parameters can be affected by comorbidities or the interaction of drugs with food. Objectives: This study aimed to determine the effect of food intake upon pharmacokinetics …

es, gb, pe (code pays fourni par la source)

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

Ghaith Aljayyoussi, Victoria A. Jenkins, Raman Sharma, Alison Ardrey et autres

Tuberculosis (TB) treatment is long and complex, typically involving a combination of drugs taken for 6 months. Improved drug regimens to shorten and simplify treatment are urgently required, however a major challenge to TB drug development is the lack of predictive pre-clinical …

gb (code pays fourni par la source)

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

Weiqian David Hong, Peter D. Gibbons, Suet C. Leung, Richard Kwamla Amewu et autres

Abstract A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thioridazine. Combined HTS (11000 compounds) …

gb, Ghana, pt (code pays fourni par la source)

Partition and metabolic fate of dietary glycerol in target tissues of juvenile tilapia

Diego Vicente da Costa, Julia D.L. Dias, Rita Colen, Priscila Vieira Rosa et autres

Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol

R. Mlotha, David Michael Waterhouse, Fraction K. Dzinjalamala, Alison Ardrey et autres

BACKGROUND: Current guidelines for dosing of anti-TB drugs in children advocate higher doses for rifampicin and isoniazid despite limited availability of paediatric data on the pharmacokinetics of these drugs, especially from Africa, where the burden of childhood disease remains high. METHODS: Thirty …

Malawi, gb (code pays fourni par la source)

Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients

Ana Requena‐Méndez, Geraint Davies, David Michael Waterhouse, Alison Ardrey et autres

Poor response to tuberculosis (TB) therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic (PK) parameters can be affected by several factors, such as comorbidities or the interaction of TB drugs with food. This study aimed to determine the PK …

pe, es, gb (code pays fourni par la source)