Praveen Baskaran

HIV-1 promotes loss of CD4 + T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation

Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres, Brigitta Maurer et autres

ABSTRACT HIV-1 Vpr is abundantly packaged into virions and remodels host cells immediately after entry. Here, using high-efficiency HIV-1 infection protocols and unbiased proteomics in primary CD4+ T cells, we identify the T cell fate regulator TCF7 (TCF-1) as a previously unrecognized …

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Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

Xin Li, Cynthia Lebeaupin, Aikaterini Kadianaki, Clementine Druelle-Cedano et autres

Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies 1 . Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains …

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Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

Ann-Kathrin Herzfeldt, Marta Puig Gámez, Eva Maria Garrido-Martin, Lukasz Miloslaw Boryn et autres

Cytotoxic CD8 +T lymphocytes (CTLs) are key players of adaptive anti-tumor immunity based on their ability to specifically recognize and destroy tumor cells. Many cancer immunotherapies rely on unleashing CTL function. However, tumors can evade killing through strategies which are not yet …

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Author response: Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

Ann-Kathrin Herzfeldt, Marta Puig Gámez, Eva Maria Garrido-Martin, Lukasz Miloslaw Boryn et autres

Loss of membrane-bound ICAM-1, overexpression of soluble ICAM-1 or ILKAP activity in tumor cells induce resistance to antigen-specific cytotoxic T-cell-mediated killing independently from regulating antigen presentation, PD-L1 expression, IFN-γ, or TNF-α responsiveness.

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Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Daniela Schloesser, Laura Lindenthal, Julia Sauer, Kyoung‐Jin Chung et autres

Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and removal, but they also paralyzed the ability of macrophages …

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Antifibrotic Drug Nintedanib Inhibits CSF1R to Promote IL-4–associated Tissue Repair Macrophages

Carolin Kirstin Watson, Daniela Schloesser, Katrin Fundel‐Clemens, Carmen Lerner et autres

Abstract Profibrotic and prohomeostatic macrophage phenotypes remain ill-defined, both in vivo and in vitro, impeding the successful development of drugs that reprogram macrophages as an attractive therapeutic approach to manage fibrotic disease. The goal of this study was to reveal profibrotic and …

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Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen specific tumor cell killing by cytotoxic T cells

Ann-Kathrin Mattes, Marta Puig Gámez, Eva Maria Garrido-Martin, Lukasz Miloslaw Boryn et autres

Abstract Cytotoxic CD8+ T lymphocytes (CTLs) are key players of adaptive anti-tumor immunity based on their ability to specifically recognize and destroy tumor cells. Many cancer immunotherapies rely on unleashing CTL function. However, tumors can evade killing through strategies which are not …

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Automation enables high-throughput and reproducible single-cell transcriptomics library preparation

David Kind, Praveen Baskaran, Fidel Ramírez, Martin Giner et autres

Next-generation sequencing (NGS) has revolutionized genomics, decreasing sequencing costs and allowing researchers to draw correlations between diseases and DNA or RNA changes. Technical advances have enabled the analysis of RNA expression changes between single cells within a heterogeneous population, known as single-cell …

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Die genetische Evolution der in situ follikulären Neoplasie zum t(14;18)-positiven aggressiven B‑Zell-Lymphom

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann et autres

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Temporal expression profiling of GhNAC transcription factor genes in cotton cultivars under abiotic stresses

Subiramani Sivakumar, Ganesan Prem Kumar, S Vinoth, G. Siva et autres

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Universal Gene Correction Approaches for β-hemoglobinopathies Using CRISPR-Cas9 and Adeno-Associated Virus Serotype 6 Donor Templates

Andrés Lamsfus‐Calle, Alberto Daniel-Moreno, Guillermo Ureña-Bailén, Jennifer Rottenberger et autres

Mutations in the human β-globin gene are the cause of β-hemoglobinopathies, one of the most common inherited single-gene blood disorders in the world. Novel therapeutic approaches are based on lentiviral vectors (LVs) or CRISPR-Cas9-mediated gene disruption to express adult hemoglobin (HbA), or …

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A RARE CASE OF NODULAR GOITRE PRESENTING AS A HASHIMOTO'S THYROIDITIS

Punith Jain R, Praveen Baskaran