Michelle E. Kimple

Free Fatty-Acid Receptor 4 Potentiates Glucose-Stimulated Insulin Secretion in Mouse and Human Islets via Distinct Mechanisms

LAURA REININGER, MUHAMMAD H. REHMAN, Amelia Bouabcha, SARAH FERRAGNE et autres

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets

LAURA REININGER, Muhammad Hassan Rehman, Amelia Bouabcha, SARAH FERRAGNE et autres

The free fatty acid receptor FFAR4 is expressed in pancreatic islets, and its activation potentiates insulin and inhibits somatostatin (SST) secretion. We investigated the mechanisms of action of FFAR4 on hormone secretion in mouse and human islets. The effects of the FFAR4 …

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1825-P: Potentiation of Glucose-Stimulated Insulin Secretion by Free Fatty-Acid Receptor 4 Involves Distinct Mechanisms in Mouse vs. Human Islets

LAURA REININGER, MUHAMMAD H. REHMAN, SARAH FERRAGNE, Caroline Tremblay et autres

Introduction and Objective: The long-chain fatty-acid receptor FFA4 exerts beneficial effects on glucose homeostasis and is considered a potential therapeutic target for type 2 diabetes. We previously showed in mouse islets that FFA4 activation potentiates glucose-stimulated insulin secretion indirectly via inhibition of …

Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer

M. Liu, Yanlong Zhu, Sean J. McIlwain, Haotian Deng et autres

Background/Objectives: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks the sensitivity to detect micrometastatic disease. The functional assessment of NSCLC progression may provide independent information to enhance the prediction of metastatic risk. The objective of …

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An Essential Role of Gαz and RGSz1 in Peripheral Nerve Injury and Opioid Analgesic Response (Abstract ID: 159566)

Glenda Smerin, Sevasti Gaspari, Michelle E. Kimple, Venetia Zachariou

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Gαz Regulates β-Cell Cholecystokinin Expression by Direct and Indirect Mechanisms (Abstract ID: 190968)

Liam D. Hurley, Rodsy Modhurima, Dawn Belt Davis, Michelle E. Kimple

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Characterizing Plasma-based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer

M. Liu, Yanlong Zhu, Sean J. McIlwain, Allan R. Brasier et autres

Background/Objectives: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks sensitivity to detect micrometa-static disease. Functional assessment of NSCLC progression may provide independent information to enhance prediction of metastatic risk.. The objective of this study was …

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Characterizing Metabolomic Signatures for Early Metastasis in Non-Small Cell Lung Cancer Patients Undergoing Definitive Radiation Therapy

M. Liu, H. Menon, Yuming Zhu, S. Carson Callahan et autres

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Gαz-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice

Rachel J. Fenske, Haley Wienkes, Darby C. Peter, Michael D. Schaid et autres

Abstract Prostaglandin E2 (PGE2) is a key mediator of inflammation and is derived from the omega-6 polyunsaturated fatty acid, arachidonic acid (AA). In the β-cell, the PGE2 receptor, Prostaglandin EP3 receptor (EP3), is coupled to the unique heterotrimeric G protein alpha subunit, …

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The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity

Joshua C. Neuman, Austin Reuter, Kathryn A. Carbajal, Michael D. Schaid et autres

The EP3 receptor is a strong inhibitor of β-cell function and replication, suggesting it as a potential therapeutic target for the disease. Yet, EP3 has protective roles in extrapancreatic tissues. To address this, we designed β-cell-specific EP3 knockout mice and subjected them …

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EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance

Michael D. Schaid, Jeffrey M. Harrington, Grant M. Kelly, Sophia M. Sdao et autres

Of the β-cell signaling pathways altered by obesity and insulin resistance, some are adaptive while others contribute to β-cell failure. Two critical second messengers are Ca2+ and cAMP, which control the timing and amplitude of insulin secretion. Previous work has shown the …

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How my bipolar diagnosis changed my scientific career

Michelle E. Kimple

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