Mara Esposito

Germinal center interleukin-4 microniches drive tissue divergence of IgE memory B cell responses

Sergio Villazala‐Merino, Lucas Bertoia, Romain Fenouil, Mohammed Zghaebi et autres

fr, at, ar, ch, gb (code pays fourni par la source)

Recapitulating Therapeutic Failure in Human Brucellosis: A PBMC- Based Model for Intracellular Brucella melitensi

Mara Esposito, Petra Chiquet, Ikram Salah, Haneen Msarwa et autres

Human brucellosis is one of the most prevalent bacterial zoonoses worldwide, caused by Brucella spp., a facultative intracellular pathogen. Among the species, B. melitensis is considered the most virulent and infectious for humans. Despite prolonged antibiotic regimens, 5–15% of patients experience relapse, …

ch, il (code pays fourni par la source)

Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice

Aaron James Forde, Mara Esposito, Emanuela Kerschbamer, David Schreiner et autres

Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Alveolar macrophages (AM) are widely considered the primary myeloid mediators of BCG-induced lung immunity, whereas the contribution of lung interstitial macrophages (IM) remains poorly defined. …

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HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

Jean de Lima, Nivedya Swarnalekha, Claire E. Depew, Ewelina Magdalena Bartoszek et autres

A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here, we leverage the observation that during …

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Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice

Aaron James Forde, Mara Esposito, Emanuela Kerschbamer, David Schreiner et autres

Abstract Bacille Calmette–Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Studies in non-human primates show that intravenous BCG confers superior protection compared to intradermal vaccination, yet how different vaccination routes reprogram lung immunity in …

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Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses

Sergio Villazala‐Merino, Lucas Bertoia, Romain Fenouil, Myriam Moussa et autres

Abstract Immunoglobulin E (IgE) drives allergic disease, yet how memory B cells (MBCs) reactivate to produce IgE, and how tissue localization shapes recall responses, remains unclear. Using mouse models of airborne exposure to house dust mites and Alternaria , we found that …

fr, ar, ch, gb (code pays fourni par la source)

HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung

J. Lima, Nivedya Swarnalekha, Ewelina Magdalena Bartoszek, Ludivine C. Litzler et autres

Summary A deeper understanding of how tissue localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here we leverage the observation …

The putative type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella

Maren Ketterer, Petra Chiquet, Mara Esposito, Jarosław Sędzicki et autres

ABSTRACT Brucellosis is a debilitating disease caused by the Gram-negative, facultative intracellular zoonotic pathogen Brucella. En route to its intracellular replicative niche, Brucella encounters various stressful environments that may compromise envelope integrity. Here we show that the proposed type 4 secretion system …

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USP13 modulates the stability of the APC/C adaptor CDH1

Mara Esposito, Gustavo J. Gutierrez

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USP13 controls the stability of Aurora B impacting progression through the cell cycle

Mara Esposito, Hesna Begum Akman, Philippe Giron, Maria Angeles Ceregido et autres

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The Correa factor, a new democratic future for Ecuador? The outcomes of the citizens' revolution: an inner approach

Mara Esposito

Harsh trinomial: political instability high public debt, dependence on imports. The mid-nineties crisis. Correa in power: from the Alianza Pais movement. The first presidential mandate: towards a greener and stable country. Ecuador in the world. The second presidential mandate: increasing political leadership. …

Detection and Analysis of Cell Cycle-Associated APC/C-Mediated Cellular Ubiquitylation In Vitro and In Vivo

Cesyen Cedeño, Esther La Monaca, Mara Esposito, Gustavo J. Gutierrez

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