Claire E. Depew

Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice

Aaron James Forde, Mara Esposito, Emanuela Kerschbamer, David Schreiner et autres

Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Alveolar macrophages (AM) are widely considered the primary myeloid mediators of BCG-induced lung immunity, whereas the contribution of lung interstitial macrophages (IM) remains poorly defined. …

ch (code pays fourni par la source)

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

Jean de Lima, Nivedya Swarnalekha, Claire E. Depew, Ewelina Magdalena Bartoszek et autres

A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here, we leverage the observation that during …

ch, us, be (code pays fourni par la source)

Mucosal BCG vaccination reprograms lung interstitial macrophages and enhances antimicrobial defense in mice

Aaron James Forde, Mara Esposito, Emanuela Kerschbamer, David Schreiner et autres

Abstract Bacille Calmette–Guérin (BCG) is the only licensed vaccine against tuberculosis (TB) but provides inconsistent protection against disease. Studies in non-human primates show that intravenous BCG confers superior protection compared to intradermal vaccination, yet how different vaccination routes reprogram lung immunity in …

ch (code pays fourni par la source)

Determining the protective role of hepatic CD4 resident memory T-cells in Salmonella infection 3336

Jordan A. Rixon, Claire E. Depew, Stephen J. McSorley

Abstract Description Systemic infections with non-typhoidal Salmonella serovars, such as Salmonella enterica Typhimurium (STm) are a leading cause of death in sub-Saharan Africa. Currently, there are moderately effective live vaccines, but they cannot be administered to immunocompromised individuals. Therefore, it is necessary …

us, it, ch (code pays fourni par la source)

HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung

J. Lima, Nivedya Swarnalekha, Ewelina Magdalena Bartoszek, Ludivine C. Litzler et autres

Summary A deeper understanding of how tissue localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here we leverage the observation …

Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice

Kristen L. Lokken-Toyli, Vladimir E. Diaz-Ochoa, Lizbeth Camacho, Annica R. Stull-Lane et autres

Abstract In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting …

us (code pays fourni par la source)

Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells

Jordan A. Rixon, Kevin D. Fong, Claire Morris, Alana T. Nguyen et autres

Chlamydia vaccine approaches aspire to induce Th1 cells for optimal protection, despite the fact that there is no direct evidence demonstrating Th1-mediated Chlamydia clearance from the female reproductive tract (FRT). We recently reported that T-bet-deficient mice can resolve primary Chlamydia infection normally, …

us (code pays fourni par la source)

The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines

Claire E. Depew, Stephen J. McSorley

Salmonella infections cause a wide range of intestinal and systemic disease that affects global human health. While some vaccines are available, they do not mitigate the impact of Salmonella on endemic areas. Research using Salmonella mouse models has revealed the important role …

us (code pays fourni par la source)

Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18

Claire E. Depew, Alana T. Nguyen, Marissa C. Franke, Roger Sciammas et autres

CD4 tissue-resident memory T cells (TRMs) allow robust protection of barrier surfaces against pathogens. We investigated the role of T-bet in the formation of liver CD4 TRMs using mouse models. T-bet-deficient CD4 T cells did not efficiently form liver TRMs when compared …

us (code pays fourni par la source)

Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2

Claire E. Depew, Jordan A. Rixon, Stephen J. McSorley

Hepatic CD4 tissue-resident memory T cells (TRM) are required for robust protection against Salmonella infection; however, the generation of this T cell population is poorly understood. To interrogate the contribution of inflammation, we developed a simple Salmonella -specific T cell transfer system …

us (code pays fourni par la source)

Sterile liver inflammation and T cell-intrinsic T-bet expression drive the formation of Tissue Resident Memory CD4 T cells that protect against systemic Salmonella infection

Claire E. Depew, Stephen J. McSorley

Abstract Infection with Salmonella enterica serovar Typhimurium (ST) can cause invasive Non-Typhoidal Salmonellosis (iNTS), a systemic disease which kills about 150,000 people annually. In a mouse model of systemic salmonellosis, hepatic tissue resident memory (TRM) CD4 T cells provided protection against subsequent …

us (code pays fourni par la source)

Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice

Jordan A. Rixon, Claire E. Depew, Stephen J. McSorley

Protective immune responses to Chlamydia infection within the female reproductive tract (FRT) are incompletely understood. MHC class II-restricted CD4 Th1 responses are believed to be vital for bacterial clearance due to their capacity to secrete IFN-γ, but an essential requirement for T-bet-expressing …

us (code pays fourni par la source)