Christoph Schaudinn

Disinfectant tolerance of Candidozyma auris and Candida albicans biofilms evaluated using the bead assay for biofilms

Natalia M. Zmarlak-Feher, Antje Finke, Katharina Konrat, Christoph Schaudinn et autres

ABSTRACT Candidozyma auris (formerly Candida auris ) has emerged as a critical nosocomial pathogen, notable for its multidrug resistance and its capability to form biofilms that enable persistence on surfaces. Although effective disinfection strategies are urgently needed, current disinfectant efficacy standards in …

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Quatsome nanovesicles as antibacterial platform: Mechanistic insights into their activity against planktonic and biofilm Staphylococcus aureus

Mariana Korber, Amparo M. Gallardo‐Moreno, Lidia Ferrer‐Tasies, María Coronada Fernández‐Calderón et autres

Acinetobacter baumannii’s lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread

Gottfried Wilharm, Evelyn Skiebe, Andżelina Michalska, Paul G. Higgins et autres

Acinetobacter baumannii is a Gram-negative nosocomial pathogen that is notorious for its rapid development of antibiotic resistance. However, its ecology and evolution outside hospital settings remain poorly defined. Here, we demonstrate that the natural lifestyle of A. baumannii includes soil-dwelling and airborne …

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Anthrax-causing bacteria form biofilms on a soil-inspired porous glass bead model

Leonard Borst, Sabine Howaldt, Rocío Berdaguer, Christoph Schaudinn et autres

Bacillus anthracis and the emerging pathogen Bacillus cereus biovar anthracis (Bcbva) are causative agents of the lethal disease anthrax. Their ability to form highly resistant endospores enables them to persist in the environment, posing significant threats to wild herbivores, livestock, and also …

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Acinetobacter baumannii’s lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread

Gottfried Wilharm, Evelyn Skiebe, Andżelina Michalska, Paul G. Higgins et autres

Acinetobacter baumannii is a Gram-negative nosocomial pathogen that is notorious for its rapid development of antibiotic resistance. However, its ecology and evolution outside hospital settings remain poorly defined. Here, we demonstrate that the natural lifestyle of A. baumannii includes soil-dwelling and airborne …

Skin and Wound Infection Models to Test Host–Pathogen Interactions and Evaluate Topical Antimicrobial Treatments

F. Schwarz, Christin Tautz, Andreas Nitsche, Marica Grossegesse et autres

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Improving the Culture of Human Skin Explants for Use in Preclinical Testing of Wound Healing Treatments

Xiao Guo, Martina Hüging, Ursula Mirastschijski, Ulrike Blume‐Peytavi et autres

Background: Cultured human skin explants provide preclinical models to investigate drug delivery and the efficacy of topical treatments for wound healing. However, different culture conditions may affect cell viability, proliferation, and even wound healing. Since animal-derived supplements can influence the investigation of …

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Biofilm formation by the global outbreak strain of Mycobacterium chimaera results in significantly reduced efficacy of standard disinfectants

Anna M. Oschmann, Katharina Konrat, Christoph Schaudinn, Dirk Wagner et autres

BACKGROUND: In 2013, a global outbreak of Mycobacterium chimaera infections due to contaminated heater-cooler units emerged. This ongoing problem has highlighted the question of whether disinfection recommendations for medical devices containing water circuits are adequate for preventing contamination and possible recontamination by …

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Life in the brine of Lunenburg, Germany: unveiling microorganisms associated with Zechstein salt deposits

Katharina Runzheimer, Laura Schwab, Denise Engel, Christoph Schaudinn et autres

Introduction The presence of hypersaline brines on other planets and moons in the inner and outer Solar System has been well established. Hence, any theory of life on other planets must consider microorganisms adapted to high salt concentrations. The hypersaline brine from …

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Copper Stress Response of Antibiotic‐Resistant and Copper‐Tolerant Enterococcus faecium and the Antibacterial Efficacy of Functionalized Copper Surfaces

Franca Arndt, Katharina Siems, Stella Marie Timofeev, Aisha Saddiqa Ahmed et autres

Abstract The widespread use of antibiotics worldwide has led to an increase in multi‐resistant pathogens, including vancomycin‐resistant enterococci (VRE). To prevent the spread of multi‐resistant pathogens, antimicrobial surfaces have become more widely used. Various metals and surface topographies are researched to optimize …

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Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs

Fabian Kunisch, Claudia Campobasso, Jeroen Wagemans, Selma Yıldırım et autres

Spread of multidrug-resistant Pseudomonas aeruginosa strains threatens to render currently available antibiotics obsolete, with limited prospects for the development of new antibiotics. Lytic bacteriophages, the viruses of bacteria, represent a path to combat this threat. In vitro-directed evolution is traditionally applied to …

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Impact of Mycobacteroides abscessus colony morphology on biofilm formation and antimicrobial resistance

Anna Maria Oschmann-Kadenbach, Christoph Schaudinn, Leonard Borst, C. Schwarz et autres

Mycobacteroides abscessus is one of the most resistant bacteria so far known and causes severe and hard to treat lung infections in predisposed patients such as those with Cystic Fibrosis (CF). Further, it causes nosocomial infections by forming biofilms on medical devices …

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