Lidia Ferrer‐Tasies

Quatsome nanovesicles as antibacterial platform: Mechanistic insights into their activity against planktonic and biofilm Staphylococcus aureus

Mariana Korber, Amparo M. Gallardo‐Moreno, Lidia Ferrer‐Tasies, María Coronada Fernández‐Calderón et autres

Quatsome nanovesicles as antibacterial platform: Mechanistic insights into their activity against planktonic and biofilm Staphylococcus aureus

Mariana Köber, Amparo M. Gallardo‐Moreno, Lidia Ferrer‐Tasies, María Coronada Fernández‐Calderón et autres

The growing threat of antibiotic-resistant pathogens has intensified the demand for alternative antibacterial materials. Quatsomes-nanovesicles composed of cholesterol and quaternary ammonium surfactants (QAS)-emerge as promising candidates due to their intrinsic antimicrobial properties and tunable physicochemical characteristics. Here, we investigate the antibacterial activity …

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Highly homogeneous nanovesicles produced by DELOS-SUSP, a compressed fluid methodology. Application in pH-sensitive nanovesicles for DNA delivery.

David Piña Muñoz, Lidia Ferrer‐Tasies, Josep Merlo, Alba Córdoba et autres

Nanovesicles

Núria Pujol-Solé, Lidia Ferrer‐Tasies, Judit Tomsen-Melero, Agustín Carreño et autres

Nanovesicle-based nanopharmaceuticals are highly complex formulations whose efficacy and safety are highly dependent on their physico-chemical and biological characteristics, and even small deviations may result in altered pharmacokinetics, in vivo clearance, drug release kinetics and toxicity/safety profiling. While the exact set of …

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A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery

Marta Alcaina-Hernando, Ivana Malvacio, Ilaria Ferraboschi, Cristián Huck‐Iriart et autres

• Novel nanovesicles without animal-derived components have been developed. • These stable nanovesicles are formed by the self-assembly of β-sitosterol, lauryl glucoside and lauryl glucose carboxylate using the single-step DELOS methodology. • Tocopherol as a hydrophobic model molecule is efficiently loaded in …

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A New Plant-Based Drug Delivery Platform Based on Alkyl Poly Glucosides and Β-Sitosterol Nanovesicles for Topical Delivery

Marta Alcaina-Hernando, Ivana Malvacio, Ilaria Ferraboschi, Cristián Huck‐Iriart et autres

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Stable nanovesicles formed by intrinsically planar bilayers

Mariana Köber, Sílvia Illa‐Tuset, Lidia Ferrer‐Tasies, Evelyn Moreno‐Calvo et autres

HYPOTHESIS: Quatsome nanovesicles, formed through the self-assembly of cholesterol (CHOL) and cetyltrimethylammonium bromide (CTAB) in water, have shown long-term stability in terms of size and morphology, while at the same time exhibiting high CHOL-CTAB intermolecular binding energies. We hypothesize that CHOL/CTAB quatsomes …

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DELOS Nanovesicles-Based Hydrogels: An Advanced Formulation for Topical Use

Lídia Ballell‐Hosa, Elisabet González‐Mira, Héctor Santana, Judit Morlà‐Folch et autres

Topical delivery has received great attention due to its localized drug delivery, its patient compliance, and its low risk for side effects. Recent developments have focused on studying new drug delivery systems as a strategy for addressing the challenges of current topical …

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A narrative review on Epidermal Growth Factor (EGF) intralesional infiltrations for diabetic complex wounds: The rational of an innovative delivery route

Jorge Berlanga‐Acosta, Jose Fernandez-Montequin, Héctor Santana-Milián, Calixto Valdes-Perez et autres

Diabetes mellitus remains as a pandemic disease, associated to progressive and irreversible complications including lower extremity ulcerations, derived from a predisposition to ischemia, neuropathy and an intrinsic wound healing failure. The molecular operators supporting wound chronicity remain elusive, but a local deficit …

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Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing (Adv. Therap. 6/2021)

Lidia Ferrer‐Tasies, Héctor Santana, Ingrid Cabrera‐Puig, Elisabet González‐Mira et autres

In article number 2000260, Jaume Veciana, Nora Ventosa and co-workers report a soft, reliable, and scalable method based on compressed CO2 for obtaining nanoconjugates of recombinant human epidermal growth factors and nanovesicles. These nanoconjugates exhibit appropriate physicochemical properties together with an antimicrobial …

Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing

Lidia Ferrer‐Tasies, Héctor Santana, Ingrid Cabrera‐Puig, Elisabet González‐Mira et autres

Abstract A multitude of microparticles and nanoparticles is developed to improve the delivery of different small drugs and large biomolecules, which are subject to several hindering biological barriers that limit their optimal biodistribution and therapeutic effects. Here, a soft, reliable, and scalable …

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MKC-Quatsomes: a stable nanovesicle platform for bio-imaging and drug-delivery applications

Guillem Vargas‐Nadal, Mónica Muñoz-Úbeda, Patricia Álamo, Montserrat Mitjans et autres

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