Yousuke Takahama

Improved protocol for isolation and characterization of human thymic epithelial cells

Naoko Matsui, Hiroyuki Kondo, Kazuhiro Maejima, Yosuke Matsushita et autres

jp, us (code pays fourni par la source)

ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution

Pedro Ferreirinha, Pedro M. Rodrigues, Francisco Sobral, Bruno Cavadas et autres

The thymus generates immunocompetent T cells, but its function declines with age. Thymic activity relies on proper differentiation of thymic epithelial cells (TECs), which establish unique niches for T-cell development. However, the molecular mechanisms governing the differentiation of functional cortical (c) and …

pt, us, gb (code pays fourni par la source)

Thymic cortical epithelial Psmb11 -encoded β5t in mouse and human

Meiting Yang, Akihide Shimizu, Mami Matsuda‐Lennikov, J LI et autres

Psmb11-encoded β5t is a proteolytic subunit of thymoproteasomes expressed in cortical thymic epithelial cells (cTECs). β5t-containing thymoproteasomes are essential for the thymic generation of CD8-lineage cytotoxic T cells. Here, we outline the current understanding of the mechanisms underlying thymoproteasome-dependent CD8 T cell …

us, jp (code pays fourni par la source)

Proteasome alteration between epithelial and hematopoietic cells facilitates positive selection of CD8 T cells

Mami Matsuda‐Lennikov, Jamie-Jean De La Torre, Todd Snow, Jacqueline Battaile et autres

The thymoproteasome, a proteolytic complex uniquely expressed in cortical thymic epithelial cells (cTECs), governs the positive selection of CD8 T cells. It has been hypothesized that the thymoproteasome promotes CD8 T cell development by forging a sequential switch in proteasome species between …

us, jp (code pays fourni par la source)

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis

J LI, Meiting Yang, Mami Matsuda‐Lennikov, Felix Kalle-Youngoue et autres

The chemokine receptor CCR9 regulates thymus colonization by T progenitors and intestinal accumulation of TCRγδ+ intraepithelial lymphocytes (IELs). CCR9-ligand chemokine CCL25 is expressed predominantly in the thymus and the small intestine. By engineering tissue-specific CCL25-deficient mice, we demonstrate that CCL25 locally produced …

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Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides

Miho Shinzawa, Nicole Ramos, Khanh Bui, William Hajjar et autres

Abstract Thymocytes signaled by T cell antigen receptors to undergo positive selection acquire different functional fates while migrating through the thymus, but how this occurs remains uncertain. We now report that encoding CD8 co-receptors in both Cd4 and Cd8 gene loci modulates …

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Ccl21a , Rather Than Ccl21b , is Essential for Thymocyte Migration in Mouse

Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi et autres

Self-tolerance in T cells is a vital self-defense strategy for mammals to specifically respond to invading pathogens. During T cell development in the thymus, thymocytes migrate from the cortex to the medulla to sequentially acquire non-self-reactivity and self-tolerance. This cortex-to-medulla migration is …

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Author response for "Ccl21a, rather than Ccl21b, is essential for thymocyte migration in mouse"

Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi et autres

Author response for "Ccl21a, rather than Ccl21b, is essential for thymocyte migration in mouse"

Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi et autres

The cooperation between RNA binding proteins ZFP36L1 and ZFP36L2 controls thymic epithelial cell differentiation to promote thymus function.

Nuno L. Alves, Pedro Ferreirinha, Pedro M. Rodrigues, Francisco Sobral et autres

pt, us, my, gb (code pays fourni par la source)

Integrated Workflow for Chromatin Architecture Analysis in Rare Thymic Cells Using Focused Ion Beam Scanning Electron Microscopy v1

Zulfeqhar Ali Syed, Ye Sun, Mami Matsuda‐Lennikov, Yousuke Takahama et autres

The thymus, a primary lymphoid organ, plays a critical role in T-cell development and selection including the establishment of central tolerance. To investigate chromatin organisation in cells that regulate thymocyte differentiation, we developed an optimised workflow to quantify heterochromatin-to-euchromatin ratios among different …

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FGF21 keeps the thymus young

Yousuke Takahama

us (code pays fourni par la source)