Chenlin Hao

A double-antibody sandwich enzyme-linked immunosorbent assay with novel anti-VP1 monoclonal antibodies for the detection of porcine Sapelovirus

Fangting Dong, Yuhang Li, Yutong Feng, Jinwang Hu et autres

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Development of colloidal gold and carbon immunochromatographic strips for rapid detection of PDCoV

Chenlin Hao, Mengxiao Xu, Tong Bu, B Zhang et autres

Porcine deltacoronavirus (PDCoV) is an enteric coronavirus that causes diarrhea in suckling piglets, leading to serious economic losses in the swine industry. In this study, we report the development of competitive immunochromatographic strips for PDCoV detection using both colloidal gold and carbon …

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Japanese encephalitis virus NS1 and NS4B synergistically target TLR3 signaling to promote viral replication

Quan Zeng, Maozhou He, Mengyao Li, Dong Yang et autres

To establish effective infection, viral pathogens employ diverse strategies through encoded proteins to interfere with host antiviral responses. While previous studies have predominantly focused on elucidating the mechanisms by which individual viral proteins regulate type I interferon (IFN) responses, this study presents …

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Identification and characterization of two novel linear B cell epitopes on the envelope protein of Japanese encephalitis virus

Mengyao Li, Zhiyang Ran, Quan Zeng, Chenlin Hao et autres

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Identification and characterization of a novel linear B-cell epitope on nucleocapsid protein of porcine epidemic diarrhea virus

Jingwen Wang, Wei Zhang, Hao Lü, Chenlin Hao et autres

BACKGROUND: Porcine epidemic diarrhea virus (PEDV) is a highly virulent enterovirus that is responsible for severe diarrhea in neonatal piglets. For no effective vaccine or specific treatment are available, rapid and accurate diagnosis is crucial for the prevention and control of disease. …

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Corrigendum to “Identification and characterization of linear B cell epitopes of monoclonal antibodies against the S2 subunit of porcine deltacoronavirus” [Int. J. Biol. Macromol. 323 (Part 1) (September 2025) 147116]

Runze Song, Xiao Ma, Junyao Yang, Huanhuan Liu et autres

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Identification and characterization of linear B cell epitopes of monoclonal antibodies against the S2 subunit of porcine deltacoronavirus

Runze Song, Xiao Ma, Junyao Yang, Huanhuan Liu et autres

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Identification of an immunodominant neutralizing epitope of porcine astrovirus type 5 capsid protein

Yixin Hu, Zehui Li, Chenlin Hao, Hao Lü et autres

• A neutralizing monoclonal antibody against the capsid protein of PAstV5 was prepared for the first time. • The B cell epitope of PAstV5 capsid protein was identified for the first time. • The monoclonal antibody 6c6 had strong neutralizing activity against …

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Porcine deltacoronavirus nucleocapsid protein antagonizes JAK-STAT signaling pathway by targeting STAT1 through KPNA2 degradation

Yating Hu, Chenlin Hao, Donghan Wang, Guo Meng et autres

Porcine deltacoronavirus (PDCoV) is an enteric pathogenic coronavirus that causes acute and severe watery diarrhea in piglets and has the ability of cross-species transmission, posing a great threat to swine production and public health. The interferon (IFN)-mediated signal transduction represents an important …

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Insights into the response mechanisms of activated sludge system under long-term dexamethasone stress

Zhichao Liu, Qiaona Liu, Chenlin Hao, Yanmin Zhao

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Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage

Quan Zeng, Jiaqi Liu, Chenlin Hao, Bo Zhang et autres

Flaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. …

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Preparation of monoclonal antibody and identification of two novel B cell epitopes to VP1 protein of porcine sapelovirus

Chenlin Hao, Haojie Ren, Xingyi Wu, Xiangli Shu et autres

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