AMY S. SHAH

1436-P: High Prevalence of Exocrine Pancreatic Dysfunction in Pediatric Subjects with Diabetes Mellitus

Jonathan D. Tatum, Lindsey N. Hornung, Deborah A. Elder, AMY S. SHAH et autres

Introduction & Objective: This study aimed to describe the frequency of exocrine pancreatic disease in youth with diabetes mellitus (DM) to better understand the connection between diseases of the endocrine and exocrine pancreas. Methods: Data was obtained from a single center database …

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146-OR: Clustering Pediatric Type 2 Diabetes Patients Exposes Differential Responses to Therapeutic Interventions

Raymond J. Kreienkamp, Kirk Smith, Thinley Yidzin Wangden, Elizabeth T. Jensen et autres

Introduction & Objective: Diabetes is a heterogeneous disease, with patients displaying varying degrees of adiposity, beta-cell dysfunction, and insulin resistance. Ahlqvist et al. established five distinct sub-types of adult-onset diabetes, with differing disease progression and risk for complications, based on clustering of …

1304-P: MODY Calculator Overestimates MODY Probability in Multiethnic Cohort with Youth-Onset Type 2 Diabetes Phenotype

Raymond J. Kreienkamp, BEVERLEY SHIELDS, Toni I. Pollin, Mustafa Tosur et autres

Introduction & Objective: Identifying monogenic diabetes (MODY) remains a challenge for clinicians. Shields and colleagues developed a widely used MODY probability calculator (https://www.diabetesgenes.org/) based on clinical measures to assist in this decision. Because the calculator was developed in a predominantly adult White …

221-OR: Retrospective Review of Genetic Mutations and Treatments in Patients with Monogenic Diabetes of the Youth (MODY)

Lily Y Deng, AMY S. SHAH, Mansa Krishnamurthy

Monogenic diabetes results from specific genetic mutations that result in diabetes mellitus. Clinical phenotypes differ based on the genetic defect, and treatment options are driven by the underlying genetic cause. Thus, accurate genetic diagnosis and evaluation of response to treatment is essential. …

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1101-P: Glycemia after Pediatric Bariatric Surgery—Outcomes and Predictors

Stephanie R. Sisley, AMY S. SHAH, Kristen J. Nadeau, Megan Moriarty Kelsey et autres

Background: Metabolic and bariatric surgery (MBS) is a safe and efficacious treatment for children and adolescents with severe forms of obesity. However, there are few data on the effects of pre-surgical fasting insulin homeostasis measures on post-surgical weight loss or glycemia. Methods: …

985-P: Prediction Models Combining Clinical Measures Identify Participants with Youth-Onset Diabetes Who Maintain Insulin Secretion

ANGUS JONES, BEVERLEY SHIELDS, Richard A. Oram, Dana Dabelea et autres

With the high prevalence of pediatric obesity, it is challenging to accurately classify diabetes (DM) type, especially in a diverse population of youth. Maintained fasting C-peptide ≥ 0.75ng/ml (250pmol/L) , a level associated with type 2 diabetes and successful insulin withdrawal in …