Lily Y Deng

1670-P: Enteroendocrine Deficiencies in PDX1- and RFX6-MODY

Lily Y Deng, James Michael Wells, Mansa Krishnamurthy

Introduction and Objective: PDX1 and RFX6 are critical transcription factors for development of enteroendocrine cells (EECs) in the gastrointestinal (GI) tract. Heterozygous variants in these genes lead to Maturity-onset diabetes of the Young (MODY). This study aims to characterize EEC deficiencies in …

221-OR: Retrospective Review of Genetic Mutations and Treatments in Patients with Monogenic Diabetes of the Youth (MODY)

Lily Y Deng, AMY S. SHAH, Mansa Krishnamurthy

Monogenic diabetes results from specific genetic mutations that result in diabetes mellitus. Clinical phenotypes differ based on the genetic defect, and treatment options are driven by the underlying genetic cause. Thus, accurate genetic diagnosis and evaluation of response to treatment is essential. …

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Increased de novo ceramide synthesis and accumulation in failing myocardium

Ruiping Ji, Hirokazu Akashi, Konstantinos Drosatos, Xianghai Liao et autres

Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart failure (HF) undergoing placement of left ventricular assist …

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Increased de novo ceramide synthesis and accumulation in failing myocardium

Ruiping Ji, Hirokazu Akashi, Konstantinos Drosatos, Xianghai Liao et autres

Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart failure (HF) undergoing placement of left ventricular assist …

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Abstract 18978: Lysine Acetylation of Pyruvate Dehydrogenase Reduces Enzymatic Activity and Contributes to Impaired Substrate Metabolism in the Failing Myocardium

Xiaokan Zhang, Ruiping Ji, Xianghai Liao, Lily Y Deng et autres

Introduction: Many heart failure (HF) associated non-histone proteins are modified by post-translational lysine acetylation which regulates protein activity and affects cardiac function. Hypothesis: We hypothesized that acetylation of mitochondrial proteins involved in cardiac metabolism mediate metabolic changes in the failing myocardium. We …

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Abstract 20282: Increased Circulating Levels of Total and Very Long-Chain Ceramides as Markers of Abnormal Lipid Metabolism and Lipotoxicity in Patients With Chronic Stable Heart Failure

Lily Y Deng, Ruiping Ji, Raymond C. Givens, Danielle L. Templeton et autres

Introduction: Heart failure (HF) is associated with myocardial and systemic metabolic derangements. Ceramides, a class of sphingolipids, have been associated with autophagy and mitochondrial dysfun...