Deborah A. Elder

Interpreting Glucose Management Indicator and Point-of-Care Hemoglobin A1c Discrepancies in Pediatric Patients with Islet Autotransplantation and Hemoglobin A1c Under 6.5%: A Guide for TPIAT Providers

Blair London, Lindsey Hornung, Deborah A. Elder, Siobhan Tellez

Background: Glucose management indicator (GMI) value is often used without a paired hemoglobin A1c (A1c) during telehealth encounters. There are known discrepancies between GMI and A1c that have the potential to influence decision-making regarding weaning off insulin in the post-total pancreatectomy with …

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Vertical Sleeve Gastrectomy Versus Comprehensive Lifestyle Intervention for Adolescents With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Prospective Controlled Cohort Study

Toshifumi Yodoshi, Nicholas J. Ollberding, Meghan McNeill, Sanita Ley et autres

BACKGROUND: Adolescents with severe obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) lack prospective comparative evidence to select between bariatric surgery and intensive lifestyle intervention. AIMS: To compare 52-week histological and cardiometabolic outcomes of vertical sleeve gastrectomy (VSG) versus comprehensive lifestyle intervention …

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1507-P: Presurgical Diabetes Education Program Increased Preparedness for Diabetes Management after Total Pancreatectomy with Islet Autotransplantation (TPIAT)

Siobhan Tellez, Catherine Fox, ALLYSON K. ESSELL, LI LIN et autres

Introduction and Objective: Total pancreatectomy with islet autotransplantation (TPIAT) requires families to manage diabetes with insulin pumps and continuous glucose monitors post-operatively at our institution. We created a structured pre-TPIAT diabetes education program that used condition-specific content to increase the primary learner’s …

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High Rate of Exocrine Pancreatic Dysfunction in Pediatric Patients with Diabetes Mellitus

Jonathan Tatum, Lindsey Hornung, Deborah A. Elder, Amy S. Shah et autres

OBJECTIVE: This study aimed to describe the frequency of exocrine pancreatic disease in youth with diabetes. METHODS: We conducted a retrospective chart review on data that was obtained from a single-center prospectively collected database of patients with diabetes. Patients were categorized as …

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Limitations of Continuous Glucose Monitoring in the Pediatric Total Pancreatectomy With Islet Autotransplantation Population: Comparing Patient Experiences of the Dexcom and FreeStyle Libre Systems

Bhavapriya Mani, Lindsey Hornung, Chelsie L. Fellman, Maisam Abu El-Haija et autres

OBJECTIVE Continuous glucose monitoring (CGM) systems reduce self-monitoring burden compared with glucose meter use but have limitations when used after total pancreatectomy with islet autotransplantation (TPIAT). An example is false elevation of sensor readings after hydroxyurea (HU) administration, a medication often used …

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1551-P: Exploring Islet Autoantibody Positivity and β-Cell Function after Total Pancreatectomy with Islet Auto Transplantation

Oneza Kothawala, Lindsey Hornung, ANDREW R. LAVIK, Sarah Swauger et autres

Introduction and Objective: Total pancreatectomy with islet auto transplantation (TPIAT) is a non-immune model of islet transplant. The presence of islet autoantibodies post TPIAT has been observed, but the impact on β cell function is unknown. We compared measures of β cell …

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1121: ISLET AUTOANTIBODIES ARE ASSOCIATED WITH β CELL FUNCTION AND DIABETES MEASURES IN CHILDREN WITH ACUTE RECURRENT AND CHRONIC PANCREATITIS

Gila Ginzburg, Lindsey Hornung, Lee A. Denson, Amy S. Shah et autres

Islet Autoantibodies and Their Association with β Cell Function and Diabetes Measures in Children with Acute Recurrent and Chronic Pancreatitis

Gila Ginzburg, Lindsey Hornung, Lee A. Denson, Amy S. Shah et autres

Objective: In children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) circulating islet autoantibodies (Ab) may influence β-cell function. This study reports Ab prevalence in youth with ARP/CP, and investigates effects on indices of insulin secretion during mixed meal tolerance testing …

Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis

Gila Ginzburg, Lindsey Hornung, Lee A. Denson, Amy S. Shah et autres

OBJECTIVE: In children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP), circulating islet autoantibodies (auto-Ab) may influence β-cell function. This study reports Ab prevalence in youth with ARP or CP and investigates effects on indices of insulin secretion during mixed meal …

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Islet Autoantibodies and Their Association with β Cell Function and Diabetes Measures in Children with Acute Recurrent and Chronic Pancreatitis

Gila Ginzburg, Lindsey Hornung, Lee A. Denson, Amy S. Shah et autres

Objective: In children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) circulating islet autoantibodies (Ab) may influence β-cell function. This study reports Ab prevalence in youth with ARP/CP, and investigates effects on indices of insulin secretion during mixed meal tolerance testing …

Phase 1 study of quercetin, a natural antioxidant for children and young adults with Fanconi anemia

Parinda A. Mehta, Adam Nelson, Sara Loveless, Adam Lane et autres

ABSTRACT: Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure (BMF) and a predisposition to malignancy. Systemic reactive oxygen species (ROS) and increased sensitivity of FA hematopoietic progenitors to ROS play a key role in the pathogenesis …

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1436-P: High Prevalence of Exocrine Pancreatic Dysfunction in Pediatric Subjects with Diabetes Mellitus

Jonathan Tatum, Lindsey Hornung, Deborah A. Elder, AMY S. SHAH et autres

Introduction & Objective: This study aimed to describe the frequency of exocrine pancreatic disease in youth with diabetes mellitus (DM) to better understand the connection between diseases of the endocrine and exocrine pancreas. Methods: Data was obtained from a single center database …

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