Stewart Mein

FIRST DEMONSTRATION OF DISCRETE ARC THERAPY FOR CLINICAL TRANSLATION IN PANCREATIC CANCER TREATMENT

Filipa Baltazar, Thomas Tessonnier, Stewart Mein, Jakob Liermann et autres

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Neon ion radiotherapy: physics and biology

Stewart Mein, Takamitsu Masuda, Koki Kasamatsu, Taku Nakaji et autres

Abstract Neon ion ( 20 Ne) beam radiotherapy was one of the primary particle therapy candidates investigated during the clinical trials beginning in the 1970s at the Lawrence Berkely National Laboratory (LBNL), which shut down in the early 1990s. Currently, therapeutic neon …

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Range Determination by OpenPET for Helium, Carbon, Oxygen, and Neon Ion Beams

Jicheng Sun, Takamitsu Masuda, Hideaki Tashima, Chie Toramatsu et autres

At the National Institutes for Quantum Science and Technology, conventional carbon ion therapy is going to be evolved into multi-ion therapy, in which helium, carbon, oxygen and neon ion beams are utilized together to enhance the therapeutic efficacy of charged-particle therapy. When …

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In-beam range determination using an OpenPET system for helium, carbon, oxygen, and neon ion beams

Jiayao Sun, Takamitsu Masuda, Hideaki Tashima, Chie Toramatsu et autres

Abstract Objective. At the National Institutes for Quantum Science and Technology, helium, carbon, oxygen, and neon ion beams are utilized together in multi-ion therapy to enhance the therapeutic efficacy of charged-particle therapy. When accelerated ions traverse a medium, a fraction will undergo …

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Development and dosimetric verification of static SHArc: Step‐and‐shoot carbon ion arc therapy for LET d escalation in pancreatic tumors

Filipa Baltazar, Thomas Tessonnier, Stewart Mein, Jakob Liermann et autres

Abstract Background Carbon ion radiotherapy (CIRT) offers higher linear energy transfer (LET) and superior relative biological effectiveness, making it a promising option for treating hypoxic, radioresistant tumors. Spot‐scanning Hadron Arc (SHArc) therapy enables dose‐averaged LET (LET d ) escalation in the tumor …

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HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy

Lennart Volz, Peilin Liu, Thomas Tessonnier, Xiaoda Cong et autres

Purpose This work presents a proof-of-concept study of HyperSHArc, spot-scanning hadron arc (SHArc) therapy for single-isocenter stereotactic radiosurgery of multiple brain metastases (MBMs). HyperSHArc plans using proton, helium, and carbon ions were compared with state-of-the-art volumetric modulated photon arc therapy. Methods and …

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Dose Calculation Algorithms

Stewart Mein, Thomas Tessonnier, Andrea Mairani

The dose calculation algorithm is the foundation of the clinical treatment planning systems and is a fundamental component of ensuring safe and effective radiation therapy. This chapter provides an overview of dose calculation systems within proton therapy, highlighting their mechanisms and principles …

Investigating LETd optimization strategies in carbon ion radiotherapy for pancreatic cancer: a dosimetric study using an anthropomorphic phantom

Filipa Baltazar, Friderike K. Longarino, Christina Stengl, Jakob Liermann et autres

Abstract Background Clinical carbon ion beams offer the potential to overcome hypoxia‐induced radioresistance in pancreatic tumors, due to their high dose‐averaged Linear Energy Transfer (LETd), as previous studies have linked a minimum LETd within the tumor to improved local control. Current clinical …

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Oxygen consumption measurements at ultra‐high dose rate over a wide LET range

Celine Karle, Hans Liew, Thomas Tessonnier, Stewart Mein et autres

BACKGROUND: The role of radiolytic oxygen consumption for the in-vitro "Ultra-High Dose Rate" (UHDR) sparing and in-vivo FLASH effect is subject to active debate, but data on key dependencies such as the radiation quality are lacking. PURPOSE: The influence of "dose-averaged Linear …

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First Dosimetric and Biological Verification for Spot-Scanning Hadron Arc Radiation Therapy With Carbon Ions

Thomas Tessonnier, Domenico Ivan Filosa, Celine Karle, Filipa Baltazar et autres

Purpose Spot-scanning hadron arc radiation therapy (SHArc) is a novel delivery technique for ion beams with potentially improved dose conformity and dose-averaged linear energy transfer (LET d ) redistribution. The first dosimetric validation and in vitro verification of carbon ion arc delivery …

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SC17.06 RBE’S ROLE IN ION THERAPY OF PROSTATE CANCER

Judith Besuglow, Thomas Tessonnier, Stewart Mein, Tanja Eichkorn et autres

Particle arc therapy: Status and potential

Stewart Mein, S. Wuyckens, Xiaoqiang Li, Stefan Both et autres

There is a rising interest in developing and utilizing arc delivery techniques with charged particle beams, e.g., proton, carbon or other ions, for clinical implementation. In this work, perspectives from the European Society for Radiotherapy and Oncology (ESTRO) 2022 physics workshop on …

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