First Dosimetric and Biological Verification for Spot-Scanning Hadron Arc Radiation Therapy With Carbon Ions
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Le résumé fourni par la source
Purpose Spot-scanning hadron arc radiation therapy (SHArc) is a novel delivery technique for ion beams with potentially improved dose conformity and dose-averaged linear energy transfer (LET d ) redistribution. The first dosimetric validation and in vitro verification of carbon ion arc delivery is presented. Methods and Materials Intensity-modulated particle therapy (IMPT) and SHArc plans were designed to deliver homogeneous physical dose or biological dose in a cylindrical polymethyl methacrylate (PMMA) phantom. Additional IMPT carbon plans were optimized for testing different LET d -boosting strategies. Verifications of planned doses were performed with an ionization chamber, and a clonogenic survival assay was conducted using A549 cancer lung cell line. Radiation-induced nuclear 53BP1 foci were assessed to evaluate the cellular response in both normoxic and hypoxic conditions. Results Dosimetric measurements and clonogenic assay results showed a good agreement with planned dose and survival distributions. Measured survival fractions and foci confirmed carbon ions SHArc as a potential modality to overcome hypoxia-induced radioresistance. LET d -boosted IMPT plans reached similar LET d in the target as in SHArc plans, promising similar features against hypoxia but at the cost of an increased entrance dose. SHArc resulted, however, in a lower dose bath but in a larger volume around the target. Conclusions The first proof-of-principle of carbon ions SHArc delivery was performed, and experimental evidence suggests this novel modality as an attractive approach for treating hypoxic tumors.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- First Dosimetric and Biological Verification for Spot-Scanning Hadron Arc Radiation Therapy With Carbon Ions
- Date Crossref
- 01/12/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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German Cancer Research Center Clinical Cooperation Unit Translational Radiation Oncology (E210) pays non établi dans la noticeStructure de recherche
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Heidelberg University Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Heidelberg pays non établi dans la noticeÉtablissement de santé
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Istituto Nazionale di Fisica Nucleare pays non établi dans la noticeStructure de recherche
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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Institute of Genetics and Biophysics pays non établi dans la noticeStructure de recherche
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University of Naples Federico II Radiation Biophysics Laboratory pays non établi dans la noticeUniversité ou école supérieure
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National Center for Tumor Diseases pays non établi dans la noticeOrganisme public
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RaySearch Laboratories (Sweden) pays non établi dans la noticeEntreprise
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University of Pennsylvania Department of Radiation Oncology pays non établi dans la noticeUniversité ou école supérieure
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National Center for Oncological Hadrontherapy pays non établi dans la noticeOrganisation à but non lucratif
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Clinical Cooperation Unit Radiation Oncology (E050) pays non établi dans la noticeÉtablissement de santé
Clinical Cooperation Unit Translational Radiation Oncology (E210) — German Cancer Research Center, Department of Radiation Oncology — Heidelberg University et University Hospital Heidelberg, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.