Christopher Adams

Abstract A096: Discovery of a covalent allosteric inhibitor targeting AKT1 E17K for the treatment of solid tumors

Mengqi Zhong, Subrata Shaw, Keelan Z. Guiley, Man-Tzu Wang et autres

Abstract Background A recurrent mutation in AKT1, E17K, acts as a primary oncogenic driver in select solid tumors, including breast, endometrial cancers and prostate, by promoting constitutive membrane localization and sustained kinase activation. While pan-AKT inhibitors have demonstrated clinical activity, their lack …

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A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson’s Disease

Christopher Adams

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

Mya C. Schiess, Jessika Suescun, Juan De Luigi Lemus, Charles E. Green et autres

BACKGROUND: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms. OBJECTIVES: /kg allo-hMSCs in improving motor symptoms in patients with PD (PwP). METHODS: In this phase 2, randomized, …

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Microvascular Decompression in a Patient With Positional Hemifacial Spasm: Case Report

Christopher Adams, Ali Samii, T Peckham, Manuel Marques Ferreira

BACKGROUND AND IMPORTANCE: Hemifacial spasm (HFS) is known to be caused by certain activities and, in rare cases, has been shown to be position-dependent. This is the first case of HFS caused in a patient when lying in a prone position that …

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Development of a Three-Dimensional Pathology-Simulating Model of Neurotrauma Using a Polymer-Encapsulated Neural Cell Network

Jessica Wiseman, Zoe Dombros-Ryan, Christopher Adams, Divya M. Chari

Penetrating traumatic injuries of the brain have a poor clinical prognosis necessitating development of new therapies to improve neurological outcomes. Laboratory research is hampered by reliance on highly invasive experimental approaches in living animals to simulate penetrating injuries e.g., by cutting/crushing the …

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A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson’s Disease

Christopher Adams, Greg Fulton

Background: A previous randomized pre-post cross-over study with 26 participants found positive changes in motor and non-motor symptoms in people with Parkinson’s disease (PwPD) after six weeks of group classical guitar sessions but not customary and usual treatment. Objective: To determine if …

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Author response for "A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson’s Disease"

Christopher Adams, Greg Fulton

Author response for "A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson’s Disease"

Christopher Adams, Greg Fulton

A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts

Jessica Wiseman, Raja Haseeb Basit, Akihiro Suto, Sagnik Middya et autres

JOURNAL/nrgr/04.03/01300535-202512000-00024/figure1/v/2025-01-31T122243Z/r/image-tiff Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies. Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of therapeutic biomolecules. However, a lack of facile and pathology-mimetic …

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Author response for "A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson’s Disease"

Christopher Adams, Greg Fulton

Updated Parkinson's disease motor subtypes classification and correlation to cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid levels

Christopher Adams, Jessika Suescun, Anam Haque, Kelly Block et autres

Introduction: Motor classifications of Parkinson's Disease (PD) have been widely used. This paper aims to update a subtype classification using the MDS-UPDRS-III and determine if cerebrospinal neurotransmitter profiles (HVA and 5-HIAA) differ between these subtypes in a cohort from the Parkinson's Progression …

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Future development of plastic and reconstructive surgery in Australasia

Christopher Adams

Plastic surgeons and plastic surgery services must be visible, accessible and available for patients in regions and across metropolitan centres if the specialty is to remain relevant, writes Christopher Adams.

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