Shihori Tanabe

Pan-cancer analysis of RNA expression signatures associated with cancer tissue architecture

Megumi Mogi, Katsushige Kawase, Hiroyoshi Tanaka, S. Miyata et autres

jp (code pays fourni par la source)

Adverse Outcome Pathways and Its Application in Radiation Protection—History and Recent Developments—

Nobuyuki Hamada, Shihori Tanabe

膨大な数の化学物質の安全性評価が化学物質規制の大きな課題であり，そのリスク評価に既存の生物学的知見を活用するために，有害性発現経路（AOP）の開発が精力的に進められている。近年，AOPを放射線防護分野に活用するための議論が，欧米を中心に展開され始めている。本稿では，AOP開発に関して，化学物質規制科学分野でのAOP開発，そして，放射線防護分野での活用に向けた取り組みに関する経緯と動向を紹介する。

jp, lk (code pays fourni par la source)

P18-65 Advancing the Grouping and Harmonization of Similar Key Events in the AOP Wiki: Ontology-Based Key Event Component Combinations as Catalysts for Integration

Julija Filipovska, Karine Audouze, Jonathan Blum, Laure‐Alix Clerbaux et autres

mk, fr, ch, be, us, bg, gb, it, nl, se, cz, jp (code pays fourni par la source)

Adverse Outcome Pathway (AOP) Coaching Program—how it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility

Shihori Tanabe, Tanja Burgdorf, Judy Choi, Nathalie Delrue et autres

The adverse outcome pathway (AOP) framework contributes to understanding how specific and measurable biological perturbations cause adverse effects on human and environmental health. Recognizing the value of AOPs to support regulatory decisions around the world, the Organisation for Economic Co-operation and Development …

jp, cn, de, fr, us, ch, ca, Ghana, be, it, nl, Guinée-Bissau, no (code pays fourni par la source)

Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Hiroyoshi Tanaka et autres

The coronavirus pathogenesis pathway, which consists of severe acute respiratory syndrome (SARS) coronavirus infection and signaling pathways, including the interferon pathway, the transforming growth factor beta pathway, the mitogen-activated protein kinase pathway, the apoptosis pathway, and the inflammation pathway, is activated upon …

jp, us (code pays fourni par la source)

Artificial Intelligence Approach in Machine Learning-Based Modeling and Networking of the Coronavirus Pathogenesis Pathway

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Hiroyoshi Tanaka et autres

The coronavirus pathogenesis pathway, which consists of severe acute respiratory syndrome (SARS) coronavirus infection and signaling pathways, including the interferon pathway, the transforming growth factor beta pathway, the mitogen-activated pathway kinase pathway, the apoptosis pathway, and the inflammation pathway, is activated upon …

jp, us (code pays fourni par la source)

Cheby-KANs: Advanced Kolmogorov–Arnold Networks for Applying Geometric Deep Learning in Quantum Chemistry Applications

Amgad A. Mahmoud, Andreas Pester, M. M. Muttardi, Frédéric Andrès et autres

In this work, we present an enhanced version of the Kolmogorov–Arnold network (KAN) algorithm, called Cheby-KAN, that offers a more efficient, more reliable, and faster alternative to conventional KANs. We integrated our algorithm with a geometric deep learning model (SchNet) to assess …

Égypte, jp, fr, us (code pays fourni par la source)

The mechanisms of diseases and global approaches

Shihori Tanabe, Tae-Young Kim, Rosalía Rodríguez‐Rodríguez, Chang-Beom Park

New approaches for elucidating mechanisms of diseases including environmental diseases, cancer, metabolic diseases, infectious diseases are challenging. After the presentation on elucidating the mechanism of cancer and infectious diseases, lectures by Dr. Tae-Young Kim (Korea) on metabolic deuterium oxide labeling in environmental …

kr, es (code pays fourni par la source)

Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to the RNA Virus Infection Pathway

Shihori Tanabe, Sabina Quader, Horacio Cabral, Edward J. Perkins et autres

Causal networks are important for understanding disease signaling alterations. To reveal the network pathways affected in the epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), which are related to the poor prognosis of cancer, the molecular networks and gene expression in diffuse- …

jp, us (code pays fourni par la source)

Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to RNA Virus Infection Pathway

Shihori Tanabe, Sabina Quader, Horacio Cabral, Edward J. Perkins et autres

The causal networks are important for understanding the signaling alterations in diseases. To reveal the network pathways affected in epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), which are related to poor prognosis of cancer, the molecular networks and gene expression in …

jp, us, gb (code pays fourni par la source)

The Pathway Flow Starting From Chronic Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer

Shihori Tanabe, Sabina Quader, Ryuichi Ono, Horacio Cabral et autres

The injury causes resistance in human gastric cancer (GC). This Adverse Outcome Pathway (AOP) entitled “Increases in cellular reactive oxygen species (ROS) and chronic ROS leading to human treatment-resistant gastric cancer (GC)” consists of molecular initiating event (MIE) as “Increases in cellular …

jp, gb, us (code pays fourni par la source)

Building an Adverse Outcome Pathway network for COVID-19

Penny Nymark, Laure‐Alix Clerbaux, Maria João Amorim, Christos Andronis et autres

The COVID-19 pandemic generated large amounts of data on the disease pathogenesis leading to a need for organizing the vast knowledge in a succinct manner. Between April 2020 and February 2023, the CIAO consortium exploited the Adverse Outcome Pathway (AOP) framework to …

se, it, be, pt, nl, gb, us, de, fr, jp, ca (code pays fourni par la source)