Veena G. Supramaniam

Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK ‐ FA Study

Nellie Georgiou‐Karistianis, Louise A. Corben, Eric F. Lock, Helena Bujalka et autres

OBJECTIVE: We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. METHODS: TRACK-FA is the largest prospective, longitudinal, multi-modal neuroimaging study in …

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Neuroimaging Biomarkers for Friedreich Ataxia: A Cross-Sectional Analysis of the TRACK-FA Study

Nellie Georgiou-Karistianis, Louise A. Corben, Marcondes C França, Anthony S. Gabay et autres

Georgiou-Karistianis, Nellie; Corben, Louise A; Lock, Eric F; Bujalka, Helena; Adanyeguh, Isaac; Corti, Manuela; Deelchand, Dinesh K; Delatycki, Martin B; Dogan, Imis; Farmer, Jennifer; França, Marcondes C; Gabay, Anthony S; Gaetz, William; Harding, Ian H; Joers, James; Lax, Michelle A; Li, Jiakun; …

Novel biomarkers of preterm brain injury from blood transcriptome in sheep model of intrauterine asphyxia

Carl Joakim Ek, Mårten Alkmark, Ana A. Baburamani, Veena G. Supramaniam et autres

BACKGROUND: Infants born preterm have a higher incidence of neurological deficits. A key step in finding effective treatments is to identify biomarkers that reliably predict outcome. METHODS: Following umbilical cord occlusion (UCO) in pregnant sheep, whole fetal blood RNA was sequenced pre- …

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Assessment of radial glia in the frontal lobe of fetuses with Down syndrome

Ana A. Baburamani, Regina Vontell, Alena U. Uus, Maximilian Pietsch et autres

Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated with deviations in cortical development evidenced by simplified gyral appearance and reduced cortical surface area. Radial glia are neuronal and glial progenitors that also create a scaffolding structure essential …

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Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Helen B. Stolp, Bobbi Fleiss, Yoko Arai, Veena G. Supramaniam et autres

Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). The mechanism of grey matter injury in …

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Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia

Regina Vontell, Veena G. Supramaniam, Alice Davidson, Claire Thornton et autres

Neuronal heterotopia are ectopic nodules of nerve cells that failed to migrate appropriately during the early development of the fetal brain. Subcortical and periventricular neuronal heterotopia have been described previously in association with agenesis of the corpus callosum (ACC). Most common neuronal …

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Dysmaturation of Somatostatin Interneurons Following Umbilical Cord Occlusion in Preterm Fetal Sheep

Maryam Ardalan, Pernilla Svedin, Ana A. Baburamani, Veena G. Supramaniam et autres

Introduction: Cerebral white matter injury is the most common neuropathology observed in preterm infants. However, there is increasing evidence that gray matter development also contributes to neurodevelopmental abnormalities. Fetal cerebral ischemia can lead to both neuronal and non-neuronal structural–functional abnormalities, but less …

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Bestrophin-3 Expression in a Subpopulation of Astrocytes in the Neonatal Brain After Hypoxic-Ischemic Injury

Veronika Golubinskaya, Regina Vontell, Veena G. Supramaniam, Josephine Wyatt‐Ashmead et autres

Bestrophin-3, a potential candidate for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. We studied the expression and alternative splicing of bestrophin-3 in neonatal mouse brain and after hypoxic-ischemic (HI) injury and in human neonatal brain samples. HI brain …

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Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury

Claire-Marie Rangon, Anne‐Laure Schang, Juliette Van Steenwinckel, Leslie Schwendimann et autres

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Brain Development and Perinatal Vulnerability to Cerebral Damage

Luca Antonio Ramenghi, Monica Fumagalli, Veena G. Supramaniam

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γδ T Cells Contribute to Injury in the Developing Brain

Xiaoli Zhang, Regina Vontell, Dan Bi, Roderick Terry Bronson et autres

Brain injury in premature infants, especially periventricular leukomalacia, is an important cause of neurologic disabilities. Inflammation contributes to perinatal brain injury development, but the essential mediators that lead to early-life brain injury remain largely unknown. Neonates have reduced capacity for mounting conventional …

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Effect of Trp53 gene deficiency on brain injury after neonatal hypoxia-ischemia

Ana A. Baburamani, Kristina S. Sobotka, Regina Vontell, Carina E. Mallard et autres

// Ana A. Baburamani 1, 2 , Kristina S. Sobotka 2 , Regina Vontell 1 , Carina Mallard 2 , Veena G. Supramaniam 1 , Claire Thornton 1 , Henrik Hagberg 1, 2 1 Perinatal Brain Injury Group, Centre for the Developing …

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