Renata Shen

Autism- and intellectual disability-associated MYT1L mutation alters human cortical interneuron differentiation, maturation, and physiology

Ramachandran Prakasam, Julianna J. Determan, Gareth Chapman, Mishka Narasimhan et autres

Myelin transcription factor 1 like (MYT1L) is a neuronal transcription factor highly expressed in the developing and adult brain, and, while pathogenic MYT1L mutations cause neurodevelopmental disorders, these have not been characterized in human models of neurodevelopment. Here, we modeled the consequences …

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Autism and Intellectual Disability-Associated MYT1L Mutation Alters Human Cortical Interneuron Differentiation, Maturation, and Physiology

Ramachandran Prakasam, Julianna J. Determan, Mishka Narasimhan, Renata Shen et autres

SUMMARY MYT1L is a neuronal transcription factor highly expressed in the developing and adult brain. While pathogenic MYT1L mutation causes neurodevelopmental disorders, these have not been characterized in human models of neurodevelopment. Here, we defined the consequences of pathogenic MYT1L mutation in …

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Leveraging Community Resources and Local Expertise to Build a Safe Learning Environment for K-12 Students During COVID-19: A Field Experience

Evelyn Masterson, Sarita Chung, Renata Shen, Bindiya Singh et autres

OBJECTIVE: To share the experiences of stakeholders in a school district's response to the COVID-19 pandemic, especially related to supporting the district in the reopening process and sharing key decision points, challenges, facilitators, and overall lessons learned that may be applied to …

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Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons

Irene Antony, Mishka Narasimhan, Renata Shen, Ramachandran Prakasam et autres

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Faculty Opinions recommendation of Autism genes converge on asynchronous development of shared neuron classes.

Kristen L. Kroll, Renata Shen, Irene Antony

Contributors

Irene Antony, Meagan E. Beckerson, Haley M. Bednarz, Elizabeth L. Berg et autres

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Cellular and molecular neurobiology of autism spectrum disorder

Gareth Chapman, Irene Antony, Mishka Narasimhan, Renata Shen et autres

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Faculty Opinions recommendation of Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.

Kristen L. Kroll, Renata Shen, Irene Antony