Irene Antony

Review: Child Psychiatry in the Era of Genomics: The Promise of Translational Genetics Research for the Clinic

Sarah E. Fitzpatrick, Irene Antony, Erika L. Nurmi, Thomas V. Fernandez et autres

Objective: There has been remarkable progress in recent years in understanding the genetic underpinnings of child psychiatric disorders. Concurrently, genetic testing is becoming increasingly available in the clinic. However, many clinicians report a lack of familiarity with genetics and how genetic testing …

us (code pays fourni par la source)

Rare variation in non-coding regions with evolutionary signatures contributes to autism spectrum disorder risk

Taehwan Shin, Janet H. T. Song, Michael Kosicki, Connor J. Kenny et autres

Little is known about the role of non-coding regions in the etiology of autism spectrum disorder (ASD). We examined three classes of non-coding regions: human accelerated regions (HARs), which show signatures of positive selection in humans; experimentally validated neural VISTA enhancers (VEs); …

us (code pays fourni par la source)

Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk

Taehwan Shin, Janet H. T. Song, Michael Kosicki, Connor J. Kenny et autres

Abstract Little is known about the role of noncoding regions in the etiology of autism spectrum disorder (ASD). We examined three classes of noncoding regions: Human Accelerated Regions (HARs), which show signatures of positive selection in humans; experimentally validated neural Vista Enhancers …

us, fr (code pays fourni par la source)

Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons

Irene Antony, Mishka Narasimhan, Renata Shen, Ramachandran Prakasam et autres

us (code pays fourni par la source)

Derivation of cortical interneurons from human pluripotent stem cells to model neurodevelopmental disorders

Kesavan Meganathan, Ramachandran Prakasam, Komal Kaushik, Irene Antony et autres

us (code pays fourni par la source)

Contributors

Irene Antony, Elizabeth D. Buttermore, Gerarda Cappuccio, Juan Cruz Casabona et autres

Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2

Emily M. A. Lewis, Gareth Chapman, Komal Kaushik, Julianna J. Determan et autres

Mutations in the chromodomain helicase DNA binding protein 2 (CHD2) gene are associated with neurodevelopmental disorders. However, mechanisms by which CHD2 regulates human brain development remain largely uncharacterized. Here, we used a human embryonic stem cell model of cortical interneuron (hcIN) development …

us (code pays fourni par la source)

Faculty Opinions recommendation of Autism genes converge on asynchronous development of shared neuron classes.

Kristen L. Kroll, Renata Shen, Irene Antony

Contributors

Irene Antony, Meagan E. Beckerson, Haley M. Bednarz, Elizabeth L. Berg et autres

us, ie, de, gb, dk, ca (code pays fourni par la source)

Cellular and molecular neurobiology of autism spectrum disorder

Gareth Chapman, Irene Antony, Mishka Narasimhan, Renata Shen et autres

us (code pays fourni par la source)

Faculty Opinions recommendation of Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.

Kristen L. Kroll, Renata Shen, Irene Antony

Faculty Opinions recommendation of A chromatin accessibility atlas of the developing human telencephalon.

Kristen L. Kroll, Mishka Narasimhan, Irene Antony