Slobodan D. Obradovic

Coronary-type stent implantation in chronic thromboembolic pulmonary hypertension: a national registry case series

Boris Džudović, Ivica Djuric, Jovan Matijašević, Zoran Jović et autres

BACKGROUND: Balloon pulmonary angioplasty (BPA) and pulmonary endarterectomy (PEA) are established treatments for chronic thromboembolic pulmonary hypertension (CTEPH). In cases where BPA is ineffective, stent implantation emerges as salvage therapy. However, stent implantation during BPA remains a subject of debate. METHODS: This …

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Cardiovascular comorbidities and risk stratification in normotensive acute pulmonary embolism patients with right ventricular dysfunction and normal cardiac troponin: insights from a regional registry

Boris Džudović, Ivica Djuric, Bojana Subotić, Jovan Matijašević et autres

Abstract Background Acute pulmonary embolism (PE) management guidelines categorize normotensive patients with right ventricle dysfunction (RVD) and normal cardiac troponin (cTn) as intermediate low risk. This study explores the prevalence of cardiovascular comorbidities and their impact on risk stratification in this specific …

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Apert Syndrome with Agenesis of the Corpus Collosum - Case Report

Jelena Nestorovic–Tanaskovic, Zoran R. Igrutinovic, Biljana Vuletić, Маrija Radovanovic et autres

Abstract Apert syndrome (Acrocephalosyndactylia type 1) belongs to the group of extremely rare congenital dysmorphic syndromes. It is characterized by craniostenosis with very early fusion of the skull and / or cranial base sutures, facial hypoplasia, symmetrical syndactyly of the fingers and …

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Evolution of Neurosonographic Findings After Periventricular/Intraventricular Hemorrhage

Маrija Radovanovic, Slobodan D. Obradovic, Aleksandra M. Simovic, Raša Medović et autres

Background: Periventricular/intraventricular hemorrhage (PVH/IVH) has a major impact on neurodevelopment due to its complications and sequelae. Objectives: This study aimed to determine the frequency of neurosonographic examination and the length of the monitoring period in children diagnosed with PVH/IVH. Methods: This clinical …

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Moyamoya syndrome in Schimke immuno-osseous dysplasia

Ana Vujić, Slobodan D. Obradovic, Zoran R. Igrutinovic, Zoran Protrka et autres

Introduction. Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive multisystem disorder associated with biallelic mutations of the SMAR-CAL1 gene. Vascular central nervous system complications in the form of Moyamoya syndrome (MMS) have been reported as a comorbidity in nearly half of …

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Platelets in Ulcerative Colitis: From Pathophysiology to Therapy

Stanko Petrović, Slobodan D. Obradovic, Marijana Petrović, Nemanja Rančić

Based on the role of platelets in inflammation and hemostasis it has been assumed that antiplatelet therapy could be beneficial for patients suffering from ulcerative colitis. Platelets present a link between inflammation and coagulation. They have more than 300 active mediators stored …

Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

Nina Đukanović, Slobodan D. Obradovic, Marija D. Zdravkovic, Siniša Đurašević et autres

Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase …

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MS SQL server and MySQL response speed comparation

Ilja Stanišević, Mlađen Vićentić, Slobodan D. Obradovic

In order to select database managmeent tool (i.e., DBMS) for information system developed for Valjevo Business School, testing of two available options (i.e. MS SQL and MySQL) was performed. Instead of using available benchmark software, simple software to test features relevant to …

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Predictive Value of Heart Failure with Reduced versus Preserved Ejection Fraction for Outcome in Pulmonary Embolism

Slobodan D. Obradovic, Boris Džudović, Bojana Subotić, Jovan Matijašević et autres

AIMS: This study aimed to investigate whether the risk of short-term mortality is different in pulmonary embolism (PE) patients who have heart failure with reduced ejection fraction (HFrEF) as compared with those with heart failure with preserved ejection fraction (HFpEF). METHODS AND …

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Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer’s Disease Diagnosis

Edin Begić, Sunčica Hadžidedić, Slobodan D. Obradovic, Zijo Begić et autres

BACKGROUND: Alzheimer's disease is a complex disorder of unclear etiology that develops in the elderly population. It is a debilitating, progressive neurodegeneration for which disease-modifying therapies do not exist. Previous studies have suggested that, for a subset of patients, dysregulation in hemostasis …

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Antiplatelet agents’-ticagrelol and eptifibatide-safety in experimental colitis in mice

Stanko Petrović, Milijana Vasiljevska, Slobodan D. Obradovic, Dino K. Tarabar et autres

BACKGROUND/AIMS: To evaluate the side effects of two antiplatelet agents - ticagrelor and eptifibatide - in mice with experimentally-induced inflammatory bowel disease. METHODS AND MATERIAL: This study was designed as a controlled, animal, drug safety investigation. C57Bl/6 mice were used to establish …

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The influence of workloads and depth queue on the performance of SSD disk RAID 0 level array

Nikola Davidović, Slobodan D. Obradovic, Borislav Đorđević, Valentina V. Timcenko

The RAID 0 level represents a group of N independent disks. The data is written consecutively in blocks to various hardware units. This procedure increases the total storage space. Since the capacity of SSD devices is relatively small, connecting them into a …

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