Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer’s Disease Diagnosis
Rattachement africain : ba, gb, rs. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Alzheimer's disease is a complex disorder of unclear etiology that develops in the elderly population. It is a debilitating, progressive neurodegeneration for which disease-modifying therapies do not exist. Previous studies have suggested that, for a subset of patients, dysregulation in hemostasis might be one of the molecular mechanisms that ultimately leads to the development of neurodegeneration resulting in cognitive decline that represents the most prominent symptomatic characteristic of Alzheimer's disease. OBJECTIVE: To examine a relationship between factors that are part of coagulation and anticoagulation pathways with cognitive decline that develops during Alzheimer's disease. METHODS: SOMAscan assay was used to measure levels of coagulation/anticoagulation factors V, VII, IX, X, Xa, XI, antithrombin III, protein S, protein C, and activated protein C in plasma samples obtained from three groups of subjects: 1) subjects with stable cognitively healthy function, 2) subjects with stable mild cognitive impairment, and 3) subjects diagnosed with probable Alzheimer's disease. RESULTS: Our results show that protein levels of coagulation factor XI are significantly increased in patients who are diagnosed with probable Alzheimer's disease compared with cognitively healthy subjects or patients diagnosed with mild cognitive impairment. Furthermore, our results demonstrate that significant predictors of Alzheimer's-type diagnosis are factors IX and XI-an increase in both factors is associated with a reduction in cognitive function. CONCLUSION: Our study justifies further investigations of biological pathways involving coagulation/anticoagulation factors in relation to dementia, including dementia resulting from Alzheimer's-type neurodegeneration.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer’s Disease Diagnosis
- Date Crossref
- 01/09/2020
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Sarajevo School of Science and Technology Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
-
Academy of Medical Sciences of Bosnia and Herzegovina pays non établi dans la noticeOrganisation à but non lucratif
-
Durham University Department of Computer Science pays non établi dans la noticeUniversité ou école supérieure
-
Military Medical Academy pays non établi dans la noticeÉtablissement de santé
-
University of Sarajevo Department of Pediatric Cardiology pays non établi dans la noticeUniversité ou école supérieure
-
Clinical Center University of Sarajevo pays non établi dans la noticeÉtablissement de santé
-
General Hospital “Prim.Dr. Abdulah Nakas” Department of Cardiology pays non établi dans la noticeÉtablissement de santé
-
University of Defense Clinic for Emergency and Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
-
E-mail: pays non établi dans la noticeInstitution
-
Fax: +387 33 975 030 pays non établi dans la noticeInstitution
Department of Pharmacology — Sarajevo School of Science and Technology, Academy of Medical Sciences of Bosnia and Herzegovina et Department of Computer Science — Durham University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.