Accès ouvert
2026
article
OpenAlex
Oscar Vivas, Matthias Baudot, Roxanne Madden, Wendy L. Piñon-Teal et autres
BACKGROUND: Every heartbeat is initiated by a spontaneous electrical signal generated inside the cardiac pacemaker. This signal depends on the coordinated activity of ion channels, where voltage-gated L-type calcium channels play a central role. All mammals experience a progressive decline in pacemaker …
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Accès ouvert
2024
article
OpenAlex
Víctor A. Flores-Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor et autres
Background Increased vascular Ca V 1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothesize that α1 C phosphorylation at serine 1928 …
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2024
article
OpenAlex
Galina Yu. Mironova, Miguel Martín‐Aragón Baudel, Víctor A. Flores-Tamez, Suzanne E. Brett et autres
L-type calcium (Ca2+) channels hold a pivotal position in governing intracellular Ca2+ concentration within smooth muscle and the establishment of myogenic tone. Their primary regulatory mechanism has historically been linked to voltage. Nevertheless, it remains a subject of inquiry whether voltage represents …
ca, us
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Accès ouvert
2022
article
OpenAlex
Miguel Martín‐Aragón Baudel, Víctor A. Flores-Tamez, Junyoung Hong, Gopyreddy R. Reddy et autres
Background: L-type Ca V 1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. This study tests the hypothesis that phosphorylation of the Ca V 1.2 pore-forming subunit α1 C at S1928 mediates vascular Ca V 1.2 cooperativity during …
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2021
article
OpenAlex
Miguel Martín‐Aragón Baudel, Víctor A. Flores-Tamez, Gopyreddy R. Reddy, Junyoung Hong et autres
The L‐type Ca 2+ channel Ca V 1.2 plays key roles in cell excitability, muscle contraction and gene expression. These channels have been shown to gate in unison (e.g. coupled gating) in several cell types. Ca V 1.2 coupling amplifies Ca 2+ …
us
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2021
article
OpenAlex
Galina Yu. Mironova, Miguel Martín‐Aragón Baudel, Víctor A. Flores-Tamez, Manuel F. Navedo et autres
Intravascular pressure elicits arterial constriction by elevating intracellular [Ca 2+ ] in vascular smooth muscle cells (SMCs). Past studies have argued that this rise is singularly linked to depolarization and the voltage‐dependent gating of L‐type (Ca V 1.2) Ca 2+ channels. While …
ca, us
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Accès ouvert
2021
article
OpenAlex
Thanhmai Le, Miguel Martín‐Aragón Baudel, Arsalan U. Syed, Navid Singhrao et autres
Abstract Cigarette smoke, including secondhand smoke (SHS), has significant detrimental vascular effects, but its effects on myogenic tone of small resistance arteries and the underlying mechanisms are understudied. Although it is apparent that SHS contributes to endothelial dysfunction, much less is known …
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Accès ouvert
2020
article
OpenAlex
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín‐Aragón Baudel et autres
Abstract The L-type Ca 2+ channel Ca V 1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca 2+ channel via PKA, but the underlying mechanisms are unclear. Here, we find that …
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Accès ouvert
2020
article
OpenAlex
Madeline Nieves‐Cintrón, Víctor A. Flores-Tamez, Thanhmai Le, Miguel Martín‐Aragón Baudel et autres
Abstract Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality in diabetes is hyperglycemia, which contributes to the pathogenesis of cardiovascular complications. These cardiovascular complications are, at least in part, …
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Accès ouvert
2019
article
OpenAlex
Víctor A. Flores-Tamez, Bruno Escalante, Amelia Rı́os
Several studies have shown that peroxynitrite (ONOO-), formed upon the reaction of •NO and O2-, is increased in many cardiovascular diseases and is detrimental to myocardial function. Proteins associated with Ca2+ homeostasis regulation in the heart may be involved in these effects. …
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