Manzhao Ouyang

Modified Negative Pressure Drainage with Primary Closure vs. Rhomboid Flap for Stoma Reversal: A Comparative Study of Surgical Site Infection

Huacong Huang, Yongying Cen, Yongle Ju, Manzhao Ouyang et autres

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Impact of Preoperative Anemia on Short-Term Outcomes After Colorectal Cancer Surgery: How the Choice of Diagnostic Criteria Leads to Conflicting Findings

Wangji Li, Yuanhong Peng, Changda Ye, Yan Lu et autres

Background: Whether preoperative anemia is independently associated with short-term postoperative outcomes in colorectal cancer (CRC) remains controversial. This study investigated the association between preoperative anemia and 30-day postoperative complications (PO30C) and evaluated how different anemia diagnostic criteria influence this association. Methods: In …

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Identification of copper metabolism-related subtypes, the development of a prognosis model, and characterization of the immune landscape in colorectal cancer

Lin Zhong, Nan Lai, Lina Luo, Fu Cheng et autres

OBJECTIVE: Abnormalities in copper metabolism are implicated in colorectal cancer (CRC) progression and unfavorable survival outcomes. Although there has been a recent surge of studies on cuprotosis-related genes, most have not elucidated the relationship between copper and tumors from the perspective of …

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Skin flap graft closure with modified negative pressure drainage: A new approach

Jiazhi Wang, Huacong Huang, Xiaoying Ye, Manzhao Ouyang et autres

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Clinical prediction model for anastomotic leakage in rectal cancer surgery: a single-center large-sample cohort study

Xiaojiang Yi, Chuangqi Chen, Jingfang Diao, Hongming Li et autres

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Establishing the relationships between obesity and genetically predicted serum micronutrient levels: a multivariable Mendelian randomization analysis

Rui Zhou, Yanxiang Zhang, Jiazhi Wang, Huacong Huang et autres

BACKGROUND: Previous observational studies have indicated that circulating micronutrients may influence obesity risk. This study aimed to explore the causal relationship between micronutrient levels and obesity through multivariable Mendelian randomization (MR) analysis. METHODS: Single nucleotide polymorphisms (SNPs) significantly associated with 15 micronutrients …

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Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study

Wen-Kai Li, Jing Wang, Jie Lin, Lei Sun et autres

Background: Mixed adenoneuroendocrine carcinoma (MANEC) is rare and heterogeneous. Currently, there is no concise treatment standard for MANEC. This study aimed to explore the prognostic impact of different treatment methods in MANEC. Methods: The surveillance, epidemiology and end results database was utilized …

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

Zhiwei He, Yan Lü, Kang Wang, Yuanhong Peng et autres

Background: Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many …

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Role of disulfidptosis in colorectal adenocarcinoma: implications for prognosis and immunity

Ruanruan Yang, Chunxiao Lai, Luji Huang, Feng Li et autres

Background: Recent research has found a new way of cell death: disulfidptosis. Under glucose starvation, abnormal accumulation of disulfide molecules such as Cystine in Solute Carrier Family 7 Member 11 (SLC7A11) overexpression cells induced disulfide stress to trigger cell death. The research …

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Analysis of decision-making factors for defunctioning ileostomy after rectal cancer surgery and their impact on perioperative recovery: a retrospective study of 1082 patients

Xiaojiang Yi, Huaguo Yang, Hongming Li, Xiaochuang Feng et autres

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Disulfidptosis-related long non-coding RNA signature predicts the prognosis, tumor microenvironment, immunotherapy, and antitumor drug options in colon adenocarcinoma

Kang Wang, Jing Yu, Qihuan Xu, Yuanhong Peng et autres

This study aims to investigate the role and prognostic significance of long non-coding RNAs (lncRNAs) associated with disulfidptosis in colon adenocarcinoma (COAD). The TCGA database's clinical data and transcriptome profiles were employed. Analysis of previous studies identified 10 disulfidptosis-related genes (DRGs). We …

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Role of long non-coding RNAs in metabolic reprogramming of gastrointestinal cancer cells

Kang Wang, Yan Lu, Haibin Li, Jun Zhang et autres

Metabolic reprogramming, which is recognized as a hallmark of cancer, refers to the phenomenon by which cancer cells change their metabolism to support their increased biosynthetic demands. Tumor cells undergo substantial alterations in metabolic pathways, such as glycolysis, oxidative phosphorylation, pentose phosphate …

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