Lei Sun

LncRNA NEAT1 restrains the malignant biological characteristics of acute myeloid leukemia via regulating CTCF/CXCR2 axis

Yanquan Liu, Zuotao Li, Jingdong Zhang, Jianzhen Shen et autres

Acute myeloid leukemia (AML) is notorious in the field of hematology for its poor efficacy, frustrating prognosis, and it is prone to refractory or relapsed conditions. Previous studies in our team have shown that some Long noncoding RNAs (lncRNAs) and chemokine receptors …

cn (code pays fourni par la source)

The Tenth NTIRE 2025 Efficient Super-Resolution Challenge Report

Bin Ren, Hang Guo, Lei Sun, Zongwei Wu et autres

This paper presents a comprehensive review of the NTIRE 2025 Challenge on Single-Image Efficient Super-Resolution (ESR). The challenge aimed to advance the development of deep models that optimize key computational metrics, i.e., runtime, parameters, and FLOPs, while achieving a PSNR of at …

it, cn, bg, de, ch (code pays fourni par la source)

The Tenth NTIRE 2025 Efficient Super-Resolution Challenge Report

Bin Ren, Hang Guo, Lei Sun, Zongwei Wu et autres

This paper presents a comprehensive review of the NTIRE 2025 Challenge on Single-Image Efficient Super-Resolution (ESR). The challenge aimed to advance the development of deep models that optimize key computational metrics, i.e., runtime, parameters, and FLOPs, while achieving a PSNR of at …

Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study

Wen-Kai Li, Jing Wang, Jie Lin, Lei Sun et autres

Background: Mixed adenoneuroendocrine carcinoma (MANEC) is rare and heterogeneous. Currently, there is no concise treatment standard for MANEC. This study aimed to explore the prognostic impact of different treatment methods in MANEC. Methods: The surveillance, epidemiology and end results database was utilized …

cn (code pays fourni par la source)

GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses

Lei Sun, Jinwen Luan, Jinbiao Wang, Xiaoli Li et autres

• Gene expression profiles of RNA-seq-based exercise responses (GEPREP) stands as the inaugural comprehensive data atlas of RNA-sequencing (RNA-seq) based exercise-responsive gene expression profiles, encompassing multiple species, tissues, and exercise modalities. • GEPREP provides meticulous meta-data annotations for each profile, ensuring inclusion …

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VHUT-cryo-FIB, a method to fabricate frozen hydrated lamellae from tissue specimens for in situ cryo-electron tomography

Jianguo Zhang, Danyang Zhang, Lei Sun, Gang Ji et autres

cn (code pays fourni par la source)

Fungal Immunomodulatory Protein from Nectria haematococca Suppresses Growth of Human Lung Adenocarcinoma by Inhibiting the PI3K/Akt Pathway

Yingying Xie, Shuying Li, Lei Sun, Shujun Liu et autres

(FIP-nha) has potential as a lung cancer therapeutic; as such, illuminating its anti-tumor mechanism is expected to facilitate novel treatment options. Here, we showed that FIP-nha affects lung adenocarcinoma growth ex vivo and in vivo. Comparative quantitative proteomics showed that FIP-nha negatively …

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c-Abl-mediated Drp1 phosphorylation promotes oxidative stress-induced mitochondrial fragmentation and neuronal cell death

Qiang Zhang, Peng Zhang, Lei Sun, Can Peng et autres

Oxidative stress-induced mitochondrial dysfunction and neuronal cell death have important roles in the development of neurodegenerative diseases. Dynamin related protein 1 (Drp1) is a critical factor in regulating mitochondrial dynamics. A variety of posttranslational modifications of Drp1 have been reported, including phosphorylation, …

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Large scale three-dimensional reconstruction of an entire Caenorhabditis elegans larva using AutoCUTS-SEM

Xixia Li, Gang Ji, Xi Chen, Wei Ding et autres

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Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo

Yue Zhou, Ruijun Deng, Mingming Zhen, Jie Li et autres

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Three-dimensional super-resolution protein localization correlated with vitrified cellular context

Bei Liu, Yanhong Xue, Wei Min Zhao, Yan Chen et autres

We demonstrate the use of cryogenic super-resolution correlative light and electron microscopy (csCLEM) to precisely determine the spatial relationship between proteins and their native cellular structures. Several fluorescent proteins (FPs) were found to be photoswitchable and emitted far more photons under our …

cn (code pays fourni par la source)

Analysis of chromatin fibers in Hela cells with electron tomography

Xiaomin Li, Hongli Feng, Jianguo Zhang, Lei Sun et autres

The presence and folding pattern of chromatin in eukaryotic cells remain elusive and controversial. In this study, we prepared ultra-thin sections of Hela cells with three different fixation and sectioning methods, i.e., chemical fixation, high pressure freezing with freeze substitution, and cryo-ultramicrotomy …

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