Xiaoying Ye

Integrative transcriptomic and physiological analysis uncovers subspecies-preferred regulatory mechanisms of mercury tolerance in Indica and Japonica rice

Jun Zhu, Haipeng Tang, Zhenchao Wang, Siqi Feng et autres

Mercury (Hg) is a widespread heavy metal pollutant that threatens the safe production of rice, yet the molecular responses of the two major rice subspecies, indica and japonica , to Hg stress remain inadequately characterized. Here, we integrated physiological and biochemical analyses …

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Research on Multi-strategy Adaptive Framework for Retrieval-Augmented Generation

Gaoying Che, Fuken Zhou, Xiaoying Ye, Jiajia Gu

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Characterization of Chlorophyll Degradation Genes Reveals Gene Cluster HuSGR2 and HuSGR3 Promoting Chlorophyll Degradation in Pitaya Peel

Wenting Wu, Tian Yang, Yun Lan, Zeyu Zheng et autres

Background: Chlorophyll degradation is a characteristic sign of fruit ripening. However, the chlorophyll degradation pathway during pitaya fruit development remains unexplored. Methods and Results: Here, chlorophyll contents showed a downward trend across the five developmental stages of ‘Jindu No.1’ pitaya peels. Based …

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OsSSID6 Negatively Regulates Salt Stress Tolerance in Rice (Oryza Sativa L.) via Metabolic Pathways and ROS Scavenging

Xiaofei Zan, Hao Chen, Jiali Zhu, Mingfei Chen et autres

Soil salinization is becoming a huge threat to reducing productivity of rice (Oryza sativa L.) around the world. Previous studies have found that some Domain of unknown function (DUF) proteins play an essential role in the growth and development of plants. The …

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Nutritional Intervention with Selenium-Rich Rice Mitigates Arsenic-Induced Liver and Kidney Toxicity in Mice

Muhammad Zahir Ahsan, Faiz Hussain Panhwar, Xiaomei Jia, Xiaoying Ye et autres

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OsLEML2 Regulates Rice Thermotolerance Through Auxin and ROS Homeostasis

Xingzhuo Sun, Yuwei Wang, Yulin Chen, Peng Zhang et autres

Escalating global warming threatens rice (Oryza sativa L.) growth and yield, making research into thermotolerance mechanisms imperative. OsLEML2, identified as a heat-responsive gene through microarray screening, was investigated in this study. It was found that overexpression of OsLEML2 reduces thermotolerance in transgenic …

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Selenium Supplementation Mitigates Copper-Induced Systemic Toxicity via Transcriptomic Reprogramming and Redox Homeostasis in Mice

Faiz Hussain Panhwar, Muhammad Zahir Ahsan, Xiaomei Jia, Xiaoying Ye et autres

Copper is an essential trace element that supports numerous physiological functions; however, excessive copper accumulation can disrupt cellular and biological processes. In this study, forty-eight male mice were randomly divided into four groups (n = 12): Control (fed normal rice), Cu300 (300 …

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Overexpression of OsDUF846.2 enhances the sensitivity of rice to salt and heat stresses

Jiali Zhu, Ziyi Wang, Xuejiao Chen, Mingfei Chen et autres

Soil salinity and heat stress are major abiotic stress factors restricting rice growth, development, and yield potential. DUFs (Domains of Unknown Function) are proteins with structurally conserved but functionally undefined domains, widely present across organisms. The DUF846 family has been demonstrated to …

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Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design

Peng Zhao, John S. Schardt, Chi-I Chiang, Pooja Shah et autres

T-cell engagers (TCEs) represent a powerful drug modality for redirecting a patient’s own T cells to recognize and eradicate cancer cells. Although TCEs have been effective in treating hematological cancers, their broad application for solid tumors has been more challenging due to …

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Skin flap graft closure with modified negative pressure drainage: A new approach

Jiazhi Wang, Huacong Huang, Xiaoying Ye, Manzhao Ouyang et autres

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Ambient air pollution exposure, mediating biomarkers and risk of COPD: a cohort study and meta-analysis

Tinggui Wang, Mengdan Liang, Xiaoying Ye, Xiaoxiao Huang et autres

Background Limited evidence exists on air pollution's systemic impact on lung function and mediating biomarkers. This study comprehensively evaluated associations between air pollution, COPD and lung function, while exploring biomarker mediation. Methods A prospective analysis of 451 566 UK Biobank participants was …

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Association between household air pollution from solid fuel use and respiratory health: Results from two national prospective cohort studies

Tingting Xu, Xiaoying Ye, Guohui Lan, Mengdan Liang et autres

Previous studies have shown that household air pollution (HAP) from solid fuel use affects respiratory health, but few have explored the mechanisms associated with chronic respiratory diseases (CRDs). In this study, we investigated the association between HAP and CRDs using CHARLS and …

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