Giuseppe Passantino

Liver stem cell tumorigenesis in gilthead sea bream induced by B[a]P toxicity: In vitro insights

Maria Santacroce, Nicola Pugliese, Carmine Merola, Rosa Anna Leone et autres

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Digital droplet PCR-based detection and quantification of ovine papillomavirus DNA from the vaginal virobiota of healthy mares

Anna Cutarelli, Giuseppe Passantino, Elisabetta Razzuoli, Francesco Paolo Serpe et autres

There are four genotypes of ovine papillomaviruses (OaPVs): OaPV1, OaPV2, and OaPV4, which are ovine delta papillomaviruses responsible for epithelial and mesenchymal cell infections, and OaPV3, an epitheliotropic Dyokappapapillomavirus associated with cutaneous tumors in sheep, including squamous cell carcinoma. Vaginal swabs of …

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Solid lipid nanoparticles for Anle 138b administration in Parkinson disease: towards an industrial scale up with nutraceutical formulations

Stefano Castellani, Rosanna Mallamaci, Nicola Zizzo, Giuseppe Passantino et autres

INTRODUCTION Anle 138b, a novel drug for geriatric application in Parkinson's disease (PD), suffers from low water solubility and, hence, low bioavailability (1-2). Therefore, the research on novel water-soluble products as a vehicle for Anle 138b still represents a challenge for the …

Slightly viscous dispersions of mucoadhesive polymers as vehicles for nasal administration of dopamine and grape seed extract-loaded solid lipid nanoparticles

Stefano Castellani, Rosanna Mallamaci, Elvira De Giglio, Antonello Caponio et autres

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Relationship between Fat Status, Stage of Gonadal Maturity and Hormonal Variation of Turdus philomelos (C.L. Brehm, 1831) Wintering in Apulia during 2018–2020

Simona Tarricone, Antonella Tinelli, Giuseppe Passantino, Nicola Zizzo et autres

In this study, we aimed to evaluate the development of the fattening condition and the reproductive status of the song thrush from December to February. For this purpose, the chemical and fatty acid compositions of the pectoral muscle were analyzed in relation …

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Effect of rearing system (free-range vs cage) on gut and muscle histomorphology and microbial loads of Italian White breed rabbits

Caterina Losacco, Antonella Tinelli, Angela Dambrosio, Nicoletta Cristiana Quaglia et autres

OBJECTIVE: The growing consumers' interest on animal welfare has raised the request of products obtained by alternative rearing systems. The present study was conducted to assess the influence of housing system on gut and muscle morphology and on microbial load in rabbits …

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Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions

Fatima Maqoud, Nicola Zizzo, Marcella Attimonelli, Antonella Tinelli et autres

Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in cancer is poorly described. Pituitary macroadenoma has been observed in Cantu’ syndrome (C.S.), which is associated with the gain-of-function mutations of the ABCC9 and KCNJ8 genes. We tested the role …

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Accidental Oleandrum (Nerium Oleander L.) Ingestion: Anatomo-Pathological consequences in livestock species

A Tinelli, Giuseppe Passantino, Antonella Perillo, Nicola Zizzo

The oleander (Nerium oleander L.) is a flowering and evergreen shrub or small tree, belonging to the Dogbane family, cultivated as ornamental plants in gardens and public city areas. These plants, distributed originally in Asia and Mediterranean area, grow in many parts …

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Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells

Adriana Trapani, Stefano Castellani, Lorenzo Guerra, Elvira De Giglio et autres

We have already formulated solid lipid nanoparticles (SLNs) in which the combination of the neurotransmitter dopamine (DA) and the antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson's disease (PD) treatment. In fact, GSE supply would reduce …

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Thoracic and Abdominal Mesothelioma in an Older Horse in Lazio Region

Giuseppe Passantino, Emilio Sassi, Ilaria Filippi, Valerio Serata et autres

A Quarter Horse, a gelding aged 22, was subjected to a clinical examination for colic syndrome. During admission to the clinic, blood counts and ultrasound examination were performed. Ultrasound revealed abdominal masses and abundant accumulation of pleural (50 L) and abdominal fluid …

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Ex-Vivo Evaluation of “First Tip Closing” Radiofrequency Vessel Sealing Devices for Swine Small Intestinal Transection

Luca Lacitignola, Alberto Maria Crovace, Giuseppe Passantino, Francesco Staffieri

This study compared burst pressure (BP), number of activations, and histological assessment of ex vivo swine small intestine loops transected by stapler, a single fulcrum radiofrequency vessel sealing (RFVS) device, and the newly-developed jaws RFVS. Fifty (n = 50) 20 cm long …

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Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome

Rosa Scala, Fatima Maqoud, Nicola Zizzo, Giuseppe Passantino et autres

(1) Background: Cantu syndrome (CS) arises from gain-of-function (GOF) mutations in the ABCC9 and KCNJ8 genes, which encode ATP-sensitive K+ (KATP) channel subunits SUR2 and Kir6.1, respectively. Most CS patients have mutations in SUR2, the major component of skeletal muscle KATP, but …

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